Global Patent Index - EP 0596034 A4

EP 0596034 A4 19950524 - PURIFICATION OF RECOMBINANT CILIARY NEUROTROPHIC FACTOR AND C-TERMINAL TRUNCATED CILIARY NEUROTROPHIC FACTOR AND METHODS FOR TREATING PERIPHERAL NERVE DAMAGE.

Title (en)

PURIFICATION OF RECOMBINANT CILIARY NEUROTROPHIC FACTOR AND C-TERMINAL TRUNCATED CILIARY NEUROTROPHIC FACTOR AND METHODS FOR TREATING PERIPHERAL NERVE DAMAGE.

Title (de)

REINIGUNG VON CILIARY NEUROTROPHIC FACTOR (CNTF) UND VON C-TERMINAL VERKÜRZTEN CNTF UND VERFAHREN ZUR BEHANDLUNG VON SCHÄDIGUNGEN PERIPHEREN NERVEN.

Title (fr)

PURIFICATION DU FACTEUR NEUROTROPHIQUE CILIAIRE RECOMBINE ET DU FACTEUR NEUROTROPHIQUE CILIAIRE TRONQUE A TERMINAISON C ET PROCEDES DE TRAITEMENT DES LESIONS DE NERFS PERIPHERIQUES.

Publication

EP 0596034 A4 19950524 (EN)

Application

EP 92917747 A 19920721

Priority

  • US 9206136 W 19920721
  • US 73553891 A 19910723
  • US 75317691 A 19910830

Abstract (en)

[origin: WO9302206A1] Methods are provided for the production and purification of recombinant ciliary neurotrophic factor. The purification of C-terminal truncated forms of ciliary neurotrophic factor are also described. Methods are provided for preventing and treating peripheral nerve damage. The method comprises administering to patients in need thereof a therapeutically effective amount of CNTF. A preferred method for producing CNTF is by recombinant DNA technology.

IPC 1-7

C12P 21/06; C07K 3/00; A01N 37/18

IPC 8 full level

A61K 38/00 (2006.01); A61P 25/02 (2006.01); C07K 14/475 (2006.01); C07K 14/48 (2006.01); C07K 14/52 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 25/02 (2017.12); C07K 14/475 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [PXY] EP 0446931 A1 19910918 - FIDIA SPA [IT]
  • [E] WO 9310233 A1 19930527 - FIDIA SPA [IT]
  • [XY] A. NEGRO ET AL: "Synthesis, purification, and characterization of human ciliary neurotrophic factor from E.coli", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 29, 1991, pages 251 - 260
  • [Y] L-F LIN ET AL: "Isolation and characterization of ciliary neurotrpohic factor from rabbit sciatic nerves", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 15, 25 May 1990 (1990-05-25), BALTIMORE US, pages 8942 - 8947
  • [YA] G. BARBIN ET AL: "Purification of the chick eye ciliary neurothropic factor", JOURNAL OF NEUROCHEMISTRY, vol. 43, no. 5, 1984, pages 1468 - 1478
  • [A] S. SAADAT ET AL: "Ciliary neurotrpohic factor induces cholinergic differentiation of rat sympathetic neurons in culture", JOURNAL OF CELL BIOLOGY, vol. 108, May 1989 (1989-05-01), pages 1807 - 1816
  • [PXY] J. MCDONALD ET AL: "Expression and characterization of recombinant human ciliary neurotrphic factor from Escherichia coli", BIOCHIMICA BIOPHYSICA ACTA, vol. 1090, no. 1, 30 August 1991 (1991-08-30), pages 70 - 80
  • See references of WO 9302206A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9302206 A1 19930204; AU 2443292 A 19930223; AU 666327 B2 19960208; CA 2113815 A1 19930204; EP 0596034 A1 19940511; EP 0596034 A4 19950524; FI 940302 A0 19940121; FI 940302 A 19940121; HU 9400133 D0 19940530; HU T67352 A 19950328; IE 922402 A1 19930127; IL 102607 A0 19930114; JP H07500725 A 19950126; MX PA92004329 A 20050401; NO 940194 D0 19940119; NO 940194 L 19940208; NZ 243691 A 19951221

DOCDB simple family (application)

US 9206136 W 19920721; AU 2443292 A 19920721; CA 2113815 A 19920721; EP 92917747 A 19920721; FI 940302 A 19940121; HU 9400133 A 19920721; IE 922402 A 19920723; IL 10260792 A 19920722; JP 50305793 A 19920721; MX 9204329 A 19920723; NO 940194 A 19940119; NO 949194 A 19940119; NZ 24369192 A 19920723