Global Patent Index - EP 0598837 A4

EP 0598837 A4 19940713 - AMINO ACID, ESTER AND/OR CATECHOL CONTRAST AGENTS FOR MRI.

Title (en)

AMINO ACID, ESTER AND/OR CATECHOL CONTRAST AGENTS FOR MRI.

Publication

EP 0598837 A4 19940713 (EN)

Application

EP 92918470 A 19920807

Priority

  • US 9206660 W 19920807
  • US 74314391 A 19910809
  • US 74447091 A 19910812

Abstract (en)

[origin: WO9303351A1] The present invention relates to the preparation of amino acid containing compounds which also have multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono and di-amino acids (and their carboxylic esters carboxylic amides, and catechols) of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.

IPC 1-7

G01N 24/08

IPC 8 full level

A61B 5/055 (2006.01); A61K 49/00 (2006.01); A61K 49/06 (2006.01); A61K 51/04 (2006.01); C07F 5/00 (2006.01); C07F 11/00 (2006.01); C07F 13/00 (2006.01); G01R 33/28 (2006.01)

CPC (source: EP)

A61K 49/06 (2013.01); A61K 51/048 (2013.01); G01R 33/5601 (2013.01); A61K 2123/00 (2013.01)

Citation (search report)

  • [E] WO 9300931 A1 19930121 - MALLINCKRODT MEDICAL INC [US]
  • [PX] WO 9211232 A1 19920709 - COCKBAIN JULIAN R M [GB], et al
  • [PX] US 5135737 A 19920804 - KEANA JOHN F W [US]
  • [X] EP 0413405 A2 19910220 - SCHERING AG [DE]
  • [AX] ZA 705293 B 19710428 - STAUFFER CHEMICAL CO
  • [AX] DE 2511891 A1 19761007 - GRUENENTHAL CHEMIE
  • [Y] FR 2590484 A1 19870529 - SCHERING AG [DE]
  • [A] EP 0419387 A1 19910327 - IMMUNOTECH PARTNERS [FR]
  • [YX] R.P. HOUGHTON ET AL.: "SYNTHESIS OF BIS(IMIDES) AND BIS(HALF AMIDES) OF NN'-ETHYLENEBIS(IMINODIACETIC ACID)", J. CHEM. SOC., PERKIN TRANS 1, vol. 11, 1982, pages 2693 - 2696
  • [Y] R.J. MOTEKAITIS ET AL.: "NEW MULTIDENTATE LIGANDS.", J AMER. CHEM. SOC., vol. 92, no. 14, 1970, pages 4223 - 4230
  • [A] W.H. BAKKER ET AL.: "(111IN-DTAP-D-PHE)-OCTREOTIDE, A POTENTIAL RADIOPHARMACEUTICAL FOR IMAGING OF SOMATOSTATIN RECEPTOR-POSITIVE TUMORS: SYNTHESIS, RADIOLABELING AND IN VITRO VALIDATION", LIFE SCIENCES, vol. 49, no. 22, 1991, pages 1583 - 1591
  • See references of WO 9303351A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9303351 A1 19930218; CA 2115275 A1 19930218; EP 0598837 A1 19940601; EP 0598837 A4 19940713; JP H07502725 A 19950323

DOCDB simple family (application)

US 9206660 W 19920807; CA 2115275 A 19920807; EP 92918470 A 19920807; JP 50388493 A 19920807