EP 0603312 A4 19950607 - NOVEL GABA A? RECEPTOR WITH STEROID BINDING SITES.
Title (en)
NOVEL GABA A? RECEPTOR WITH STEROID BINDING SITES.
Title (de)
NEUER GABA A-REZEPTOR MIT STEROIDBINDUNGSSTELLEN.
Title (fr)
NOUVEAU RECEPTEUR A GABA A? PRESENTANT DES SITES DE LIAISON DE STEROIDES.
Publication
Application
Priority
- US 9207613 W 19920909
- US 75951291 A 19910913
Abstract (en)
[origin: WO9305786A1] There is disclosed a GABAA receptor-chloride ionophore complex (GRC), where GABA represents gamma-aminobutyric acid, having a novel binding site, the GNR, independent of other known sites on the GRC. There is also disclosed a method for screening for agonists of the GNR by forming an expressed GRC by co-expression cDNA encoding the GRC subunits in cells and determining the ability of a steroid to modulate allosterically benzodiazepine binding to the expressed receptor complex. The figure shows the enhancement of the binding of a benzodiazepine analog to the GRC as a function of the concentration of a steroid modulator which binds to the GNR.
IPC 1-7
A61K 31/56; A61K 31/57; A61K 37/02; C07K 15/00; C12Q 1/25; C12Q 1/68; G01N 33/53
IPC 8 full level
A61K 45/00 (2006.01); A61P 25/00 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); C07K 14/705 (2013.01); C07K 14/70571 (2013.01); C07K 14/721 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- No further relevant documents disclosed
- See references of WO 9305786A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9305786 A1 19930401; AU 2657292 A 19930427; CA 2118938 A1 19930401; EP 0603312 A1 19940629; EP 0603312 A4 19950607; JP H06510999 A 19941208
DOCDB simple family (application)
US 9207613 W 19920909; AU 2657292 A 19920909; CA 2118938 A 19920909; EP 92920306 A 19920909; JP 50609593 A 19920909