Global Patent Index - EP 0604453 A4

EP 0604453 A4 19950111 - DISEASE ASSOCIATED B-CELL EPITOPES OF TPO AND USE THEREOF.

Title (en)

DISEASE ASSOCIATED B-CELL EPITOPES OF TPO AND USE THEREOF.

Title (de)

MIT ERKRANKUNGEN ZUSAMMENHÄNGENDE B-ZELLEPITOPE VON TPO UND IHRE VERWENDUNG.

Title (fr)

EPITOPES DE CELLULES B ASSOCIES A LA MALADIE DE LA PEROXYDASE TYROIDIENNE, ET LEUR UTILISATION.

Publication

EP 0604453 A4 19950111 (EN)

Application

EP 92916802 A 19920730

Priority

  • US 9206283 W 19920730
  • US 73804091 A 19910730

Abstract (en)

[origin: WO9303146A1] Disease associated B-cell epitopes of human thyroid peroxidase are described, particularly, a nine amino acid sequence corresponding to amino acids 713-721 of recombinant human thyroid peroxidase.

IPC 1-7

C12N 9/00; C12N 15/52; A61K 39/395; C07K 7/06; C07K 15/28

IPC 8 full level

G01N 33/53 (2006.01); A61K 38/44 (2006.01); A61K 39/395 (2006.01); A61P 37/00 (2006.01); C07K 7/06 (2006.01); C07K 16/40 (2006.01); C07K 16/42 (2006.01); C12N 9/04 (2006.01); C12N 9/08 (2006.01); C12P 21/08 (2006.01); G01N 33/564 (2006.01); A61K 38/00 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 37/00 (2017.12); C07K 16/40 (2013.01); C07K 16/4241 (2013.01); C12N 9/0065 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [X] R. ELISEI ET AL.: "Studies with recombinant autoepitopes of thyroid peroxidase: evidence suggesting an epitope shared between the thyroid and the gastric parietal cell", AUTOIMMUNITY, vol. 8, no. 1, 1990, pages 65 - 70
  • [X] M. LUDGATE ET AL.: "Antibodies to human thyroid peroxidase in autoimmune thyroid disease: studies with a cloned recombinant complementary deoxyribonucleic acid epitope", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 68, no. 6, June 1989 (1989-06-01), pages 1091 - 1096
  • [OX] REINHARD FINKE ET AL.: "Determination at the molecular level of a B-cell epitope on thyroid peroxidase", PROCEEDINGS OF THE INTERNATIONAL THYROID CONFERENCE, THE HAGUE, 4-8 FEBRUARY 1991. PROGRESS IN THYROID RESEARCH., February 1991 (1991-02-01), pages 437 - 439
  • [PX] R. FINKE ET AL.: "Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease", CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 73, no. 4, October 1991 (1991-10-01), pages 919 - 921
  • [PX] F. LIBERT ET AL.: "Thyroperoxidase, but not the thyrotropin receptor, contains sequential epitopes recognized by autoantibodies inrecombinant peptides expressed in the pUEX vector", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 73, no. 4, October 1991 (1991-10-01), pages 857 - 860
  • [PX] E. ZANELLI ET AL.: "Use of recombinant epitopes to study the heterogeneous nature of the autoantibodies against thyroid peroxidase in autoimmune thyroid disease", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 87, no. 1, January 1992 (1992-01-01), pages 80 - 86
  • See references of WO 9303146A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9303146 A1 19930218; AU 2403292 A 19930302; CA 2113280 A1 19930218; EP 0604453 A1 19940706; EP 0604453 A4 19950111; FI 940391 A0 19940126; FI 940391 A 19940328; JP H07503604 A 19950420; NO 940298 D0 19940127; NO 940298 L 19940127

DOCDB simple family (application)

US 9206283 W 19920730; AU 2403292 A 19920730; CA 2113280 A 19920730; EP 92916802 A 19920730; FI 940391 A 19940126; JP 50370193 A 19920730; NO 940298 A 19940127