Global Patent Index - EP 0605908 A3

EP 0605908 A3 19940817 - WATER INSOLUBLE MANGANESE PARTICLES AS MAGNETIC RESONANCE, IMAGING CONTRAST ENHANCEMENT AGENTS.

Title (en)

WATER INSOLUBLE MANGANESE PARTICLES AS MAGNETIC RESONANCE, IMAGING CONTRAST ENHANCEMENT AGENTS.

Publication

EP 0605908 A3 19940817 (EN)

Application

EP 93203303 A 19931126

Priority

US 99189392 A 19921217

Abstract (en)

[origin: EP0605908A2] A magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese salt is described, together with a method of preparing the composition, which advantageously also contains a surfactant, which comprises contacting a manganese source with a counter ion source for a time and under conditions sufficient for the formation of said insoluble manganese salt. Preferably the organ rich in mitochondria is the liver, the particles are substantially nonmagnetic with a preferred particle size of less than about 10 microns and the insoluble manganese salt selected from the group consisting of manganese phosphate and manganese carbonate. A method of diagnosis comprising administering to a mammal a contrast effective amount of a composition of the particles is also described.

IPC 1-7

A61K 49/00; A61K 33/32

IPC 8 full level

A61K 49/00 (2006.01); A61K 33/32 (2006.01); A61K 49/18 (2006.01); A61N 2/00 (2006.01); C01G 45/00 (2006.01)

CPC (source: EP KR US)

A61K 33/32 (2013.01 - EP KR US); A61K 47/12 (2013.01 - KR); A61K 47/22 (2013.01 - KR); A61K 47/24 (2013.01 - KR); A61K 49/1818 (2013.01 - EP US); A61K 49/1821 (2013.01 - EP KR US); Y10T 436/24 (2015.01 - EP KR US)

Citation (search report)

  • [X] EP 0184899 A1 19860618 - NYEGAARD & CO AS [NO]
  • [X] EP 0240424 A1 19871007 - UNIV RENNES [FR]
  • [X] GB 2012162 A 19790725 - MCCOLLESTER DUNCAN LEE
  • [X] EP 0052874 A1 19820602 - MARX GERARD
  • [PX] WO 9307905 A2 19930429 - MALLINCKRODT MEDICAL INC [US]
  • [X] SCHAEFER, SAUL. ET AL: "Experimental Studies: In Vivo Nuclear Magnetic Resonance Imaging of Myocardial Perfusion Using the Paramagnetic Contrast Agent Manganese Gluconate.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1989, VOL. 14, NO. 2, PAGES 472-480.
  • [PX] OKSENDAL, A.N. ET AL: "BIODISTRIBUTION AND TOXICITY OF MR IMAGING CONTRAST MEDIA.", JOURNAL OF MAGNETIC RESONANCE IMAGING., JAN-FEB. 1993, VOL. 3, NO.1, PAGES 157-165.
  • [PX] SUR.SK. ET AL: "MAGNETIC RELAXATION IN ALUMINOSILICATE STRUCTURES CONTAINING MANGANESE(II) AND GADOLINIUM(III) COMPLEXES.", JOURNAL OF MAGNETIC RESONANCE SERIES A, 1 JUNE 1993, VOL. 103, NO.1, PAGES 27-33.

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

EP 0605908 A2 19940713; EP 0605908 A3 19940817; AU 4885093 A 19940630; CA 2107695 A1 19940618; CN 1102348 A 19950510; CZ 265093 A3 19940817; FI 935309 A0 19931129; FI 935309 A 19940618; HU 9303489 D0 19940428; HU T65884 A 19940728; IL 107816 A0 19940412; JP H06199703 A 19940719; KR 940013538 A 19940715; MX 9306625 A 19940630; NO 934334 D0 19931130; NO 934334 L 19940620; NZ 248812 A 19951127; SK 142693 A3 19941005; US 5401492 A 19950328

DOCDB simple family (application)

EP 93203303 A 19931126; AU 4885093 A 19931007; CA 2107695 A 19931005; CN 93119681 A 19931027; CZ 265093 A 19931206; FI 935309 A 19931129; HU 9303489 A 19931208; IL 10781693 A 19931201; JP 27810393 A 19931108; KR 930022435 A 19931027; MX 9306625 A 19931025; NO 934334 A 19931130; NZ 24881293 A 19930929; SK 142693 A 19931215; US 99189392 A 19921217