Global Patent Index - EP 0608215 A4

EP 0608215 A4 19931111 - QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS.

Title (en)

QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS.

Title (de)

ANTINEOPLASTISCHE WIRKSTOFFE AUF DER BASIS VON CHINOBENZOXAZINEN, CHINOBENZOTHIAZINEN UND PYRIDO-ACRIDINEN.

Title (fr)

AGENTS ANTINEOPLASTIQUES A BASE DE QUINOBENZOXAZINE, DE QUINOBENZOTHIAZINES ET DE PYRIDO-ACRIDINE.

Publication

EP 0608215 A4 19931111 (EN)

Application

EP 91918185 A 19910823

Priority

  • US 9106040 W 19910823
  • US 57310290 A 19900824

Abstract (en)

[origin: WO9203136A1] Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I), as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R<1> is hydrogen or a carboxy-protecting group, R<2> and R<3> are substituents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.

IPC 1-7

A61K 31/44; A61K 31/50; A61K 31/54; A61K 31/495; A61K 31/535; C07D 221/22; C07D 279/36; C07D 513/00; C07D 221/04; C07D 471/06; A61K 31/47; C07D 498/06; C07D 513/06; C07D 455/02

IPC 8 full level

C07D 455/03 (2006.01); C07D 498/06 (2006.01); C07D 498/16 (2006.01); C07D 513/06 (2006.01)

CPC (source: EP)

C07D 455/00 (2013.01); C07D 513/06 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

  • [X] ZA 853071 B 19851224 - ABBOTT LAB
  • [X] EP 0324298 A1 19890719 - ESTEVE LABOR DR [ES]
  • [T] CHU D.T.W. ET AL.: "SYNTHESIS AND ANTITUMOUR ACTIVITIES OF QUINOLONE ANTINEOPLASTIC AGENTS", DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, vol. XVIII, no. 7, 1992, pages 275 - 282
  • [DX] D.T.W.CHU ET AL.: "SYNTHESIS OF 4-OXO-4H-QUINO(2,3,4-i,j)(1,4)-BENOXAZINE-5-CARBOXYLIC ACID DERIVATIVES", J. HETEROCYCLIC CHEM., vol. 24, 1987, pages 453 - 456
  • [A] S. RADL ET AL.: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 3-OXO-3H-PYRIDO(3,2,1-kl)PHENOXAZINE-2-CARBOXYLIC ACIDS", COLLECT. CZECH. CHEM. COMMUN., vol. 54, 1989, pages 506 - 515, XP001013437
  • [A] P. HUSSY ET AL.: "EFFECT OF 4-QUINOLONES AND NOVOBIOCIN ON CALF THYMUS DNA POLYMERASE ALPHA PRIMASE COMPLEX, TOPOISOMERASE I AND II, AND GROWTH OF MAMMALIAN LYMPHOBLASTS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 29, no. 6, 1986, pages 1073 - 1078
  • See references of WO 9203136A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9203136 A1 19920305; CA 2099609 A1 19920225; EP 0608215 A1 19940803; EP 0608215 A4 19931111; IE 912902 A1 19920226; PT 98766 A 19920731; PT 98766 B 19990129

DOCDB simple family (application)

US 9106040 W 19910823; CA 2099609 A 19910823; EP 91918185 A 19910823; IE 290291 A 19910815; PT 9876691 A 19910823