EP 0613468 A1 19940907 - NOVEL SUBSTITUTED SALICYCLIC ACIDS.
Title (en)
NOVEL SUBSTITUTED SALICYCLIC ACIDS.
Title (de)
NEUE SUBSTITUIERTE SALIZYLSÄURE.
Title (fr)
NOUVEAUX ACIDES SALICYLIQUES SUBSTITUES.
Publication
Application
Priority
- SE 9103397 A 19911118
- SE 9200758 W 19921104
Abstract (en)
[origin: WO9310094A1] A compound of the formula Het-NR-SO2?-Ph?2-A-Ph?1 (COOH)(OH) and tautomic form, salts, solvates, C1-6? alkyl esters and pharmaceutical compositions of the compound. Ph?1 and Ph?2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.
Abstract (fr)
On décrit un composé de la formule Het-NR-SO2-Ph2-A-Ph1 (COOH)(OH), ses formes tautomères, sels, solvates, (C1-C6)alkyle esters, ainsi que les compositions pharmaceutiques du composé. Ph1 et Ph2 sont des noyaux benzéniques dans lesquels les groupes carboxy et hydroxy doivent être en position ortho l'un par rapport à l'autre. Le groupe Het comprend un groupe hétérocyclique (le cas échéant substitué), comportant des doubles liaisons conjuguées et lié à l'azote du groupe NR. Le composé est caractérisé par le fait que A est un pont résistant à la réduction, parce qu'il ne s'agit pas d'un groupe azo, et par le fait que R est un hydrogène ou un alkyle inférieur. L'invention concerne également la préparation du composé et son utilisation en tant que médicament, en particulier pour le traitement d'affections auto-immunes.
IPC 1-7
C07D 213/75; C07D 261/16; C07D 239/42; C07D 237/20; C07D 277/82
IPC 8 full level
A61K 31/41 (2006.01); A61K 31/415 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4418 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/4965 (2006.01); A61K 31/50 (2006.01); A61K 31/505 (2006.01); A61K 31/603 (2006.01); A61P 1/00 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 37/06 (2006.01); C07D 213/75 (2006.01); C07D 213/76 (2006.01); C07D 213/78 (2006.01); C07D 233/88 (2006.01); C07D 233/90 (2006.01); C07D 237/20 (2006.01); C07D 239/42 (2006.01); C07D 239/69 (2006.01); C07D 241/20 (2006.01); C07D 249/12 (2006.01); C07D 249/14 (2006.01); C07D 261/14 (2006.01); C07D 261/16 (2006.01); C07D 263/28 (2006.01); C07D 277/20 (2006.01); C07D 277/22 (2006.01); C07D 277/32 (2006.01); C07D 277/38 (2006.01); C07D 277/82 (2006.01)
CPC (source: EP US)
A61P 1/00 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); C07D 213/76 (2013.01 - EP US); C07D 237/20 (2013.01 - EP US); C07D 239/42 (2013.01 - EP US); C07D 261/16 (2013.01 - EP US); C07D 277/82 (2013.01 - EP US)
Citation (search report)
See references of WO 9310094A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9310094 A1 19930527; AT E194597 T1 20000715; AU 2958992 A 19930615; AU 668528 B2 19960509; CA 2123697 A1 19930527; CA 2123697 C 20031209; DE 69231252 D1 20000817; DE 69231252 T2 20010301; DK 0613468 T3 20001023; EE 03026 B1 19970815; EP 0613468 A1 19940907; EP 0613468 B1 20000712; ES 2149780 T3 20001116; FI 106857 B 20010430; FI 942289 A0 19940517; FI 942289 A 19940517; GR 3034585 T3 20010131; HU 211163 A9 19951030; HU 221476 B 20021028; HU 9401391 D0 19940829; HU T69723 A 19950928; IL 103665 A0 19930404; IL 103665 A 19970814; JP 3259915 B2 20020225; JP H07501330 A 19950209; KR 100253748 B1 20000501; LT 3182 B 19950327; LT IP229 A 19940925; LV 10246 A 19941020; LV 10246 B 19950420; MX 9206647 A 19930501; MY 130169 A 20070629; NO 300805 B1 19970728; NO 941799 D0 19940513; NO 941799 L 19940622; NZ 244998 A 19950926; PT 101068 A 19940228; PT 101068 B 19990831; RU 2124501 C1 19990110; SE 9103397 D0 19911118; SK 282080 B6 20011008; SK 54794 A3 19950208; TW 304944 B 19970511; UA 42869 C2 20011115; US 5302718 A 19940412; US 5403930 A 19950404; US 5556855 A 19960917; ZA 928864 B 19930513
DOCDB simple family (application)
SE 9200758 W 19921104; AT 92924067 T 19921104; AU 2958992 A 19921104; CA 2123697 A 19921104; DE 69231252 T 19921104; DK 92924067 T 19921104; EE 9400111 A 19941102; EP 92924067 A 19921104; ES 92924067 T 19921104; FI 942289 A 19940517; GR 20000402274 T 20001009; HU 9401391 A 19921104; HU 9500492 P 19950628; IL 10366592 A 19921106; JP 50919193 A 19921104; KR 19940701664 A 19940517; LT IP229 A 19921117; LV 920202 A 19921113; MX 9206647 A 19921118; MY PI9202100 A 19921117; NO 941799 A 19940513; NZ 24499892 A 19921103; PT 10106892 A 19921117; RU 94028109 A 19921104; SE 9103397 A 19911118; SK 54794 A 19921104; TW 81109532 A 19921127; UA 94005499 A 19921104; US 13287493 A 19931007; US 36586994 A 19941229; US 97375392 A 19921109; ZA 928864 A 19921117