EP 0617618 A1 19941005 - ARYL-TRIFLATES AND RELATED COMPOUNDS.
Title (en)
ARYL-TRIFLATES AND RELATED COMPOUNDS.
Title (de)
ARYLTRIFLATE UND VERWANDTE VERBINDUNGEN.
Title (fr)
ARYLTRIFLATES ET COMPOSES ASSOCIES.
Publication
Application
Priority
- DK 9200389 W 19921218
- SE 9103745 A 19911218
Abstract (en)
[origin: WO9311761A1] Aryltriflates and related compounds having general formula (1) wherein Ar is an aromatic or heteroaromatic system of a compound which has a therapeutic, biological activity when it, in the same position, carries a hydroxy, alkyloxy, halo, ester or cyano group; wherein R1 is CF3, (C1-C8)alkyl, -CH2-(C3-C8)cycloalkylalkyl, substituted phenyl, substituted benzyl, substituted phenylethyl, substituted phenylpropyl, substituted 2-thiophenylethyl or substituted 2-thiophenylpropyl; possess both good pharmacodynamic and good pharmacokinetic properties and are thus useful drugs.
Abstract (fr)
L'invention se rapporte à des aryltriflates et à des composés associés représentés par la formule générale (1), où Ar représente un système aromatique ou hétéroaromatique d'un composé qui possède une activité biologique thérapeutique lorsque, dans la même position, il porte un groupe hydroxy, alkyloxy, halo, ester ou cyano; où R1 représente CF3, (C1-C8)alkyle, -CH2-(C3-C8)cycloalkylalkyle, phényle substitué, benzyle substitué, phényléthyle substitué, phénylpropyle substitué, 2-thiophényléthyle substitué ou 2-thiophénylpropyle substitué. Ces composés possèdent de bonnes propriétés à la fois pharmacodynamiques et pharmacocynétiques et ils sont par conséquent utiles comme médicaments.
IPC 1-7
A61K 31/255; A61K 31/40; A61K 31/435; A61K 31/34; A61K 31/55
IPC 8 full level
C07D 243/38 (2006.01); A61K 31/00 (2006.01); A61K 31/255 (2006.01); A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01); A61K 31/382 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/435 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61K 31/451 (2006.01); A61K 31/473 (2006.01); A61K 31/485 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/18 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07C 309/65 (2006.01); C07C 309/72 (2006.01); C07C 309/75 (2006.01); C07C 309/76 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 211/32 (2006.01); C07D 213/50 (2006.01); C07D 221/10 (2006.01); C07D 221/14 (2006.01); C07D 221/18 (2006.01); C07D 221/26 (2006.01); C07D 221/28 (2006.01); C07D 223/16 (2006.01); C07D 279/28 (2006.01); C07D 307/81 (2006.01); C07D 311/74 (2006.01); C07D 333/20 (2006.01); C07D 333/34 (2006.01); C07D 333/58 (2006.01); C07D 335/06 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 455/02 (2006.01); C07D 471/04 (2006.01); C07D 489/02 (2006.01); C09D 11/00 (2006.01)
CPC (source: EP)
A61K 31/255 (2013.01); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/18 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07C 309/65 (2013.01); C07D 209/16 (2013.01); C07D 213/50 (2013.01); C07D 221/18 (2013.01); C07D 221/28 (2013.01); C07D 223/16 (2013.01); C07D 307/81 (2013.01); C07D 333/20 (2013.01); C07D 455/02 (2013.01); C07D 471/04 (2013.01); C09D 11/326 (2013.01)
Citation (search report)
See references of WO 9311761A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9311761 A1 19930624; AU 3255993 A 19930719; CA 2126242 A1 19930624; EP 0617618 A1 19941005; FI 942931 A0 19940617; FI 942931 A 19940617; JP H08504744 A 19960521; NO 942296 D0 19940617; NO 942296 L 19940617; SE 9103745 D0 19911218
DOCDB simple family (application)
DK 9200389 W 19921218; AU 3255993 A 19921218; CA 2126242 A 19921218; EP 93901666 A 19921218; FI 942931 A 19940617; JP 51053893 A 19921218; NO 942296 A 19940617; SE 9103745 A 19911218