Global Patent Index - EP 0624096 A4

EP 0624096 A4 19950419 - TAXOL AS A RADIATION SENSITIZER.

Title (en)

TAXOL AS A RADIATION SENSITIZER.

Title (de)

TAXOL ALS SENSIBILISIERUNGSMITTEL FÜR STRAHLUNG.

Title (fr)

TAXOL UTILISE COMME SENSIBILISATEUR AUX RAYONNEMENTS.

Publication

EP 0624096 A4 19950419 (EN)

Application

EP 92915821 A 19920131

Priority

  • CA 2128693 A 19920131
  • US 9200851 W 19920131

Abstract (en)

[origin: WO9314787A1] This invention provides a method of increasing sensitivity of cells to cytotoxic effects of ionizing radiation which includes incubating the cells with spindle poison in suitable carrier at a concentration effective to inhibit the cells from progressing through G2 or M phases of the cell cycle for a time effective to inhibit division of the cells and then administering a cytotoxic dose of ionizing radiation to the cells. This invention also provides a method of treating a cancer patient which comprises administering to patient a spindle poison in suitable carrier in an amount effective to inhibit tumor cells in the patient from progressing through G2 or M phases of the cell cycle for an amount of time effective to inhibit division of the tumor cells and then administering a cytotoxic dose of ionizing radiation to the patient. This invention further provides a method for increasing the sensitivity of cells to bleomycin and a kit useful for treating cancer patients.

IPC 1-7

A61K 43/00; A01N 43/02

IPC 8 full level

A61N 5/00 (2006.01); A61K 31/335 (2006.01); A61K 36/18 (2006.01); A61K 41/00 (2006.01); A61K 45/06 (2006.01); A61K 51/00 (2006.01); A61K 51/12 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP)

A61K 41/00 (2013.01); A61K 51/1282 (2013.01); A61P 35/00 (2017.12); A61K 2121/00 (2013.01)

Citation (search report)

  • [E] WO 9219765 A1 19921112 - US HEALTH [US]
  • [A] RADHEY S. GUPTA: "GENETIC, BIOCHEMICAL, AND CROSS-RESISTANCE STUDIES WITH MUTANTS OF CHINESE HAMSTER OVARY CELLS RESISTANT TO THE ANTICANCER DRUGS, VM-26 AND VP16-213.", CANCER RES., vol. 43, no. 4, April 1983 (1983-04-01), pages 1568 - 1574
  • See references of WO 9314787A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9314787 A1 19930805; AU 2333892 A 19930901; CA 2128693 A1 19930805; EP 0624096 A1 19941117; EP 0624096 A4 19950419; JP H07506341 A 19950713

DOCDB simple family (application)

US 9200851 W 19920131; AU 2333892 A 19920131; CA 2128693 A 19920131; EP 92915821 A 19920131; JP 51316393 A 19920131