Global Patent Index - EP 0626852 A4

EP 0626852 A4 19960320 - METHOD FOR MAKING UNIVERSAL DONOR CELLS.

Title (en)

METHOD FOR MAKING UNIVERSAL DONOR CELLS.

Publication

EP 0626852 A4 19960320 (EN)

Application

EP 93904719 A 19930129

Priority

  • US 9300797 W 19930129
  • US 83042792 A 19920131
  • US 94486892 A 19920914

Abstract (en)

[origin: WO9314769A1] Transplantation antigen-depleted cells and methods for making such cells from a target cell are provided. The transplantation antigen-depleted cell is made by exposing a target cell to an oligonucleotide capable of binding to a transplantation antigen nucleotide sequence. The oligonucleotide is capable of binding to the nucleotide sequence according to Watson-Crick or triplex binding rules. Preferred transplantation antigens are the MHC class I or II antigens. Oligonucleotides useful in practicing this method are also provided.

IPC 1-7

A61K 31/70; C07H 15/12; C12N 15/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61P 37/00 (2006.01); C07H 21/04 (2006.01); C12N 5/10 (2006.01); C12N 15/113 (2010.01)

CPC (source: EP)

A61K 31/70 (2013.01); A61P 37/00 (2017.12); C12N 15/1138 (2013.01); C12N 2310/15 (2013.01); C12N 2310/32 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3535 (2013.01)

Citation (search report)

  • [PX] WO 9203139 A1 19920305 - ISIS PHARMACEUTICALS INC [US]
  • [E] WO 9405333 A1 19940317 - ISIS PHARMACEUTICALS INC [US]
  • [E] EP 0601585 A2 19940615 - ENZO THERAPEUTICS INC [US]
  • [XY] GIACOMINI, P. ET AL.: "BLOCK OF TRANSLATION OF HUMAN HLA-DR-ALPHA MESSENGER RNA BY AN ANTISENSE OLIGODEOXYNUCLEOTIDE.", SEVENTH MEETING OF THE ITALIAN ASSOCIATION FOR CELL BIOLOGY AND DIFFERENTIATION, SPOLETO, ITALY, OCTOBER 16-19, 1988. EUR J CELL BIOL SUPPL 47 (23). 1988. 13
  • [XY] CHIANG, M.-Y. ET AL.: "Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 27, 25 September 1991 (1991-09-25), MD US, pages 18162 - 18171, XP002134405
  • [OXA] MATSUNAGA, T. ET AL.: "SPECIFIC INHIBITION OF BETA-2 MICROGLOBULIN GENE EXPRESSION BY ANTI-SENSE RNA IN MOUSE L CELLS.", SYMPOSIUM ON GENE TRANSFER AND GENE THERAPY HELD AT THE 17TH ANNUAL MEETINGS OF THE UCLA SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY, TAMARRON, COLORADO, USA, FEBRUARY 6-12, 1988. J CELL BIOCHEM SUPPL 0 (12 PART B), pages 202
  • See references of WO 9314769A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9314769 A1 19930805; AU 3598293 A 19930901; BR 9307844 A 19960109; CA 2126692 A1 19930805; CZ 178394 A3 19950315; EP 0626852 A1 19941207; EP 0626852 A4 19960320; HU 9402188 D0 19940928; HU T67676 A 19950428; JP H07503612 A 19950420; NO 942680 D0 19940715; NO 942680 L 19940824

DOCDB simple family (application)

US 9300797 W 19930129; AU 3598293 A 19930129; BR 9307844 A 19930129; CA 2126692 A 19930129; CZ 178394 A 19930129; EP 93904719 A 19930129; HU 9402188 A 19930129; JP 51344193 A 19930129; NO 942680 A 19940715