EP 0629184 A1 19941221 - TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS.
Title (en)
TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS.
Title (de)
TETRALINDERIVATE ALS HMG-COA REDUKTASE INHIBITOREN.
Title (fr)
DERIVES DE TETRALINE EN TANT QU'INHIBITEURS D'HMG-CoA REDUCTASE.
Publication
Application
Priority
- GB 9204810 A 19920304
- GB 9217822 A 19920821
- JP 9300266 W 19930303
Abstract (en)
[origin: WO9317991A1] This invention relates to novel tetralin derivatives having inhibitory activity against an enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase and represented by general formula (I) in which R1 is hydrogen or acetyl, R2 is carboxy and R3 is hydroxy, or R2 and R3 may form lactone, and pharmaceutical acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
Abstract (fr)
L'invention porte sur de nouveaux dérivés de tétraline ayant une activité inhibitrice contre la réductase de 3-hydroxy-3-méthylglutaryl-coenzyme A, représentés par la formule générale (I) dans laquelle R1 est hydrogène ou acétyle, R2 est carboxy et R3 est hydroxy, ou R2 et R3 peuvent former un lactone, et sels acceptables sur le plan pharmaceutique. L'invention se rapporte également à des procédés de production de ces composés, ainsi qu'à une composition pharmaceutique en renfermant.
IPC 1-7
C07C 59/54; A61K 31/19; A61K 31/35; C12P 17/06; C12P 7/42; C07C 69/732; C07D 309/30
IPC 8 full level
C12N 9/99 (2006.01); A61K 31/19 (2006.01); A61K 31/215 (2006.01); A61K 31/365 (2006.01); A61K 31/366 (2006.01); A61P 3/00 (2006.01); A61P 3/06 (2006.01); C07C 59/54 (2006.01); C07C 69/30 (2006.01); C07C 69/732 (2006.01); C07D 309/30 (2006.01); C12N 1/20 (2006.01); C12P 7/42 (2006.01); C12P 17/06 (2006.01); C12P 17/12 (2006.01); C12R 1/01 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/06 (2017.12); C07C 59/54 (2013.01); C07C 69/732 (2013.01); C07D 309/30 (2013.01); C12P 7/42 (2013.01); C12P 17/06 (2013.01); C12P 17/12 (2013.01)
Citation (search report)
See references of WO 9317991A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9317991 A1 19930916; EP 0629184 A1 19941221; JP H07504568 A 19950525
DOCDB simple family (application)
JP 9300266 W 19930303; EP 93905607 A 19930303; JP 51552893 A 19930303