Global Patent Index - EP 0630384 A4

EP 0630384 A4 19960904 - METHODS AND COMPOUNDS FOR PREVENTION OF GRAFT REJECTION.

Title (en)

METHODS AND COMPOUNDS FOR PREVENTION OF GRAFT REJECTION.

Title (de)

METHODEN UND VERBINDUNGEN ZUR VERHINDERUNG DER TRANSPLANTAT-ABSTOSSUNG.

Title (fr)

PROCEDES ET COMPOSITIONS SERVANT A LA PREVENTION DU REJET D'UNE GREFFE.

Publication

EP 0630384 A4 19960904 (EN)

Application

EP 93907073 A 19930301

Priority

  • US 9301768 W 19930301
  • US 84373192 A 19920228

Abstract (en)

[origin: WO9317043A1] Disclosed is a method of preventing graft rejection by inducing a state of local immunosuppression at the transplant site with expression of recombinant proteins by the allograft. Also disclosed is a protein suppressor factor that is secreted by cloned anergic T-cells, blocks interleukin 2 (IL-2) stimulated T-cell proliferation, has an apparent molecular weight of between 10 and 30 kilodaltons, can be inactivated by heating to 65 DEG C for 15 minutes, blocks interleukin 4 (IL-4) stimulated T-cell proliferation in vitro, is non-cytotoxic to T-cells, and does not inhibit the production of IL-2 by T-cells in vitro.

IPC 1-7

C07K 15/00; C07H 15/12; A61K 48/00

IPC 8 full level

A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); A61P 37/06 (2006.01); C07H 21/04 (2006.01); C07K 14/47 (2006.01); C07K 14/495 (2006.01); C07K 14/52 (2006.01); C07K 14/54 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C12N 15/09 (2006.01)

CPC (source: EP)

A61P 37/06 (2017.12); C07K 14/4703 (2013.01); C07K 14/4713 (2013.01); C07K 14/495 (2013.01); C07K 14/54 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

  • [X] PANKEWYCZ ET AL.: "Islet-infiltrating T-cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetes", CLIN. RES., vol. 38, no. 2, pages 408A, XP000560320
  • [PXA] DIAZ-GALLO ET AL.: "An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/ interleukin 4-dependent proliferation", PROC. NATL ACAD. SCI., vol. 89, pages 8656 - 8660, XP000199869, DOI: doi:10.1073/pnas.89.18.8656
  • [PXA] PANKEWYCZ ET AL.: "A protective NOD islet-infiltrating CD8+ T cell clone, I.S. 2.15, has in-vitro immunosuppressive properties", EUR. J. IMMUNOLOGY, vol. 22, no. 8, pages 2017 - 2023, XP000560299, DOI: doi:10.1002/eji.1830220810
  • See references of WO 9317043A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9317043 A1 19930902; AU 3780593 A 19930913; CA 2130802 A1 19930902; EP 0630384 A1 19941228; EP 0630384 A4 19960904; EP 1175910 A2 20020130; EP 1175910 A3 20040211; JP H07509119 A 19951012

DOCDB simple family (application)

US 9301768 W 19930301; AU 3780593 A 19930301; CA 2130802 A 19930301; EP 01114693 A 19930301; EP 93907073 A 19930301; JP 51509993 A 19930301