EP 0631507 A1 19950104 - SELECTIVE ALTERATION OF ANTIBODY IMMUNOGENICITY.
Title (en)
SELECTIVE ALTERATION OF ANTIBODY IMMUNOGENICITY.
Title (de)
SELEKTIVE VERANDERUNG DER ANTIKORPER-IMMUNOGENITAT.
Title (fr)
ALTERATION SELECTIVE DE L'IMMUNOGENICITE DES ANTICORPS.
Publication
Application
Priority
- CA 9300110 W 19930318
- US 85360592 A 19920318
Abstract (en)
[origin: WO9318792A1] The present invention relates to a simple process for the modification of, e.g., anti-TAA antibodies, which alters their immunogenicity so that their ability to induce an anti-isotypic response is selectively diminished, while they remain able to elecit an anti-idiotypic response. The latter is of potential immunotherapeutic value, i.e., by activation of the idiotype-anti-idiotype network. This modification takes the form of a controlled and partial reduction of the antibody; effector regions are retained. The invention should permit repeat injections (for diagnosis and therapy) and reduce HAMA interference in serodiagnostic assays.
IPC 1-7
A61K 39/395; A61K 43/00; C07K 15/28; C12P 21/08; C12N 15/13; A61K 49/02
IPC 8 full level
A61K 39/395 (2006.01); A61K 51/10 (2006.01); C07K 1/113 (2006.01); C07K 16/00 (2006.01); C07K 16/30 (2006.01); C07K 16/42 (2006.01); C12N 15/13 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 51/10 (2013.01); A61K 51/1045 (2013.01); A61K 51/1078 (2013.01); C07K 16/00 (2013.01); C07K 16/30 (2013.01); C07K 16/4208 (2013.01); C07K 16/4266 (2013.01); C07K 16/4283 (2013.01); A61K 38/00 (2013.01); A61K 2121/00 (2013.01); A61K 2123/00 (2013.01)
Citation (search report)
See references of WO 9318792A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9318792 A1 19930930; AU 3881593 A 19931021; CA 2131621 A1 19930930; EP 0631507 A1 19950104; FI 944314 A0 19940916; FI 944314 A 19940916; JP H07504668 A 19950525; NO 943388 D0 19940912; NO 943388 L 19941118
DOCDB simple family (application)
CA 9300110 W 19930318; AU 3881593 A 19930318; CA 2131621 A 19930318; EP 93907685 A 19930318; FI 944314 A 19940916; JP 51613093 A 19930318; NO 943388 A 19940912