EP 0631584 A4 19980701 - CANCER DIAGNOSIS AND THERAPY.
Title (en)
CANCER DIAGNOSIS AND THERAPY.
Title (de)
KREBS DIAGNOSE UND THERAPIE.
Title (fr)
DIAGNOSTIC ET THERAPIE DU CANCER.
Publication
Application
Priority
- US 66221691 A 19910228
- US 9201624 W 19920228
Abstract (en)
[origin: WO9215602A1] A method for determining the presence of cancerous cells in a tissue from a patient, which method includes the steps of providing either (a) a nucleic acid probe including a nucleotide sequence at least 8 nucleotides in length which is identical to a portion or all of the coding sequence of a candidate tumor suppressor gene, or (b) an antibody specific for a candidate tumor suppressor gene product; obtaining from a patient a first tissue sample potentially including cancerous cells; providing a second tissue sample, substantially all of the cells of which are non-cancerous; and comparing, by use of either the probe or the antibody, the levels of expression of the candidate tumor suppressor gene in the first and second tissue sample, wherein an amount of hybridization or immune complex formation, as the case may be, in the first tissue sample less than one third that in the second tissue sample indicates the presence of cancerous cells in the first tissue sample; methods of treating a cancerous cell by increasing the level of expression of a candidate tumor suppression gene in the cell; novel candidate tumor suppressor genes; and their use in diagnosis and therapy.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C12Q 1/6841 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5011 (2013.01); G01N 33/57484 (2013.01); A61K 38/00 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/136 (2013.01)
Citation (search report)
- [DX] BAND AND SAGER: "Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types", PROC.NATL.ACAD.SCI., vol. 86, 1989, USA, pages 1249 - 1253, XP002048605
- [X] ANISOWICZ ET AL.: "Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells", PROC.NATL.ACAD.SCI., vol. 85, 1988, USA, pages 9645 - 9649, XP002048606
- [X] YANCOPOULOS ET AL.: "Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development", PROC.NATL.ACAD.SCI., vol. 87, 1990, USA, pages 5759 - 5763, XP002048607
- [PX] LEE ET AL.: "Posistive selection of candidate tumor-suppressor genes by subtractive hybridization", PROC.NATL.ACAD.SCI., vol. 88, April 1991 (1991-04-01), USA, pages 2825 - 2829, XP002048608
- See references of WO 9215602A1
Designated contracting state (EPC)
CH DE FR GB IT LI SE
DOCDB simple family (publication)
WO 9215602 A1 19920917; CA 2104964 A1 19920829; EP 0631584 A1 19950104; EP 0631584 A4 19980701
DOCDB simple family (application)
US 9201624 W 19920228; CA 2104964 A 19920228; EP 92907799 A 19920228