EP 0636124 A1 19950201 - 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME.
Title (en)
3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME.
Title (de)
3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-1,1-DIOXID-3-CARBOSÄURE-DERIVATE, IHRE HERSTELLUNG UND DIESE ENTHALTENDE ARTZNEIMITTEL.
Title (fr)
DERIVES D'ACIDE 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXYDE-3-CARBOXYLIQUE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT.
Publication
Application
Priority
- FR 9300360 W 19930409
- FR 9204612 A 19920415
- FR 9211675 A 19921002
Abstract (en)
[origin: WO9321170A1] Compounds of formula (I), wherein R is (a) a hydrogen atom, (b) an alkyl radical, (c) an allyl radical, (d) a phenyl radical, (e) a 2-or-3-pyridyl alkyl radical, (f) a 2-quinolylalkyl radical, (g) a naphthylalkyl radical, (h) a cycloalkylalkyl radical, (i) a 2H-3-naphtho[1,8-cd]isothiazol-2-yl-1,1-dioxide)alkyl radical, (j) a (5,6-dihydro 1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolyl-2,2-dioxide)alkyl, (k) an -alk-CO-R5 radical, (l) an -alk-R6-R7 radical, (m) a 4-phenylpirerazinyl-alkyl radical wherein the phenyl nucleus is optionally substituted by one or more substituents selected from halogen atoms and alkyl or alkoxy radicals, (n) a 10-phenothiazinylalkyl radical (o) a (10-alkyl-2-phenothiazinyl)alkyl radical, (p) a 3-indolylalkyl radical, (q) a phenylalkyloxy radical, (r) a 1-phenylalkyl-4-piperidyl radical, (s) a 2-thienylalkyl radical, or (t) a phenylalkyl radical wherein the phenyl is unsubstituted or substituted by one or more substituents selected from halogen atoms and alkyl, alkoxy, polyfluoroalkyl, amino, nitro, cyano, phenyl, vinyl, polyfluoroalkoxy, alkoxycarbonyl, carboxy, phenylalkyloxy, phenylalkyl, benzoylamino, phenylcarbonyl and phenoxy radicals in which the phenyl nucleus is optionally substituted by one or more substituents selected from halogen atoms and alkyl, alkoxy or polyfluoroalkyl radicals; R1 is a carboxy, alkoxycarbonyl, tetrazolyl, -CO-NH2, -CO-NH-alk, -CO-N(alk)2, -CO-NHOH, -CO-N(alk)OH, -CO-NH-O-R8, -CO-N(alk)-OR8 or a group which is convertible in vivo into a carboxy radical; each of R2, R3 and R4, which are the same or different, is a hydrogen or halogen atom or an alkyl or alkoxy radical; R5 is a hydroxy, alkoxy, phenyl or -NR9R10 radical; R6 is an oxygen, sulphur or nitrogen atom or a SO, SO2 or -N-alk radical, R7 is an alkyl, phenylalkyl or phenyl radical optionally substituted by one or more hydrogen atoms; R8 is an alkyl or phenylalkyl radical; each of R9 and R10, which are the same or different, is a hydrogen atom or an alkyl or phenyl radical; and alk is an alkyl or alkylene radical, salts thereof; preparation thereof; and drugs containing same.
IPC 1-7
IPC 8 full level
A61K 31/54 (2006.01); A61K 31/5415 (2006.01); A61P 1/08 (2006.01); A61P 3/04 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01); A61P 25/28 (2006.01); A61P 31/12 (2006.01); A61P 43/00 (2006.01); C07D 285/24 (2006.01); C07D 417/04 (2006.01); C07D 417/06 (2006.01); C07D 513/06 (2006.01)
CPC (source: EP)
A61P 1/08 (2017.12); A61P 3/04 (2017.12); A61P 9/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/18 (2017.12); A61P 25/20 (2017.12); A61P 25/24 (2017.12); A61P 25/26 (2017.12); A61P 25/28 (2017.12); A61P 31/12 (2017.12); A61P 43/00 (2017.12); C07D 285/24 (2013.01); C07D 417/04 (2013.01); C07D 417/06 (2013.01); C07D 513/06 (2013.01)
Citation (search report)
See references of WO 9321170A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9321170 A1 19931028; AU 3957093 A 19931118; CA 2130096 A1 19931028; EP 0636124 A1 19950201; FI 944854 A0 19941014; FI 944854 A 19941014; HU 9402980 D0 19950228; HU T70955 A 19951128; IL 105390 A0 19930818; JP H07505411 A 19950615; NO 943898 D0 19941014; NO 943898 L 19941014
DOCDB simple family (application)
FR 9300360 W 19930409; AU 3957093 A 19930409; CA 2130096 A 19930409; EP 93909013 A 19930409; FI 944854 A 19941014; HU 9402980 A 19930409; IL 10539093 A 19930414; JP 51804793 A 19930409; NO 943898 A 19941014