EP 0636132 A1 19950201 - SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS.
Title (en)
SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS.
Title (de)
SUSTITUIERTE STICKSTOFF ENTHALTENDE SPIRO VERBINDUNGEN ZUR BEHANDLUNG VON KOGNITIVEN STÖRUNGEN.
Title (fr)
COMPOSES SPIRO CONTENANT DE L'AZOTE SUBSTITUE UTILISES POUR TRAITER DES DEFICITS COGNITIFS.
Publication
Application
Priority
- US 9303391 W 19930415
- US 86916392 A 19920416
Abstract (en)
[origin: WO9321185A1] There are provided novel spirocyclic compounds of formula (I), or physiologically suitable salts thereof, wherein: X and Y are taken together to form a saturated or unsaturated carbocylic or heterocyclic first ring and the shown carbon in said ring is alpha to at least one additional aromatic ring or heteroaromatic ring fused to the first ring; Z is O, S, N-NH2, 2 hydrogen atoms, or H and OH; one of Het<1> or Het<2> is 2-, 3-, or 4-pyridyl, or 2-, 4-, or 5-pyrimidinyl and the other is selected from the group including: 2-, 3-, or 4-pyridyl, 2-, 4-, or 5-pyrimidinyl, 2-pyrazinyl, 3- or 4-pyridazinyl, 3- or 4-pyrazolyl, 2- or 3-tetrahydrofuranyl, and 3-thienyl; pharmaceutical compositions containing them and method of using them in mammals to treat cognitive deficiencies and/or neurological dysfunction and/or mood disturbances as found, for example, in degenerative nervous system diseases.
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/415 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/50 (2006.01); A61K 31/505 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C07D 209/96 (2006.01); C07D 241/36 (2006.01); C07D 241/38 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/28 (2017.12); C07D 241/38 (2013.01); C07D 471/10 (2013.01)
Citation (search report)
See references of WO 9321185A1
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
WO 9321185 A1 19931028; AU 4027693 A 19931118; CA 2118212 A1 19931028; EP 0636132 A1 19950201; JP H07507772 A 19950831
DOCDB simple family (application)
US 9303391 W 19930415; AU 4027693 A 19930415; CA 2118212 A 19930415; EP 93909506 A 19930415; JP 51852093 A 19930415