EP 0636145 A1 19950201 - SYNTHETIC POLYPEPTIDES DERIVED FROM THE HIV ENVELOPE GLYCOPROTEIN.
Title (en)
SYNTHETIC POLYPEPTIDES DERIVED FROM THE HIV ENVELOPE GLYCOPROTEIN.
Title (de)
SYNTHETISCHE POLYPEPTIDE AUS DEM HIV-HÜLLEN-GLYKOPROTEIN.
Title (fr)
POLYPEPTIDES SYNTHETIQUES DERIVES DE LA GLYCOPROTEINE D'ENVELOPPE DU VIH.
Publication
Application
Priority
- GB 9300808 W 19930416
- GB 9208428 A 19920416
Abstract (en)
[origin: WO9321218A1] A synthetic polypeptide has at least one antigenic property of the envelope protein of at least one strain of Human Immunodeficiency Virus (HIV), said polypeptide consists substantially of an amino acid sequence of the formula (I): X-R1-Leu-R2-Leu-Thr-Val-Trp-Gly-R3-Lys-Y, wherein R1 is selected from Gln-Gln-R4-R5, Gln-R4-R5, R4-R5, R5 or R1 is absent; R2 is an amino acid residue selected from Gln, Lys, Glu or Arg; R3 is an amino acid residue selected from Ile, Thr or Ala; R4 is His or Glu; R5 is Leu or Met; and X and Y may each independently be absent or independently be one or more amino acid residues. Preferred peptides are (Ia): X-Gln-Gln-His-Leu-Leu-Gln-Leu-Thr-Val-Trp-Gly-Ile-Lys-Y; (Ib): X-Leu-Gln-Leu-Thr-Val-Trp-Gly-Ile-Lys-Y; (IIa) X-Gln-Gln-Glu-Met-Leu-Arg-Leu-Thr-Val-Trp-Gly-Thr-Lys-Y; and (IIb): X-Leu-Arg-Leu-Thr-Val-Trp-Gly-Thr-Lys-Y and desirably X is absent and Y is Gly-Cys or Gly-Cys-Ala. The peptides are similar to certain epitopes of HIV envelope proteins.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); A61K 39/21 (2006.01); A61K 39/395 (2006.01); A61P 31/12 (2006.01); C07K 1/10 (2006.01); C07K 1/14 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/16 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP KR)
A61K 39/21 (2013.01 - KR); A61P 31/12 (2018.01 - EP); C07K 7/06 (2013.01 - KR); C07K 7/08 (2013.01 - KR); C07K 14/005 (2013.01 - EP); C12P 21/00 (2013.01 - KR); A61K 39/00 (2013.01 - EP KR); C12N 2740/16122 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL
DOCDB simple family (publication)
WO 9321218 A1 19931028; AU 3960493 A 19931118; CA 2118033 A1 19931028; CN 1082053 A 19940216; EP 0636145 A1 19950201; GB 9208428 D0 19920603; JP H07505878 A 19950629; KR 950700933 A 19950220; ZA 932648 B 19941015
DOCDB simple family (application)
GB 9300808 W 19930416; AU 3960493 A 19930416; CA 2118033 A 19930416; CN 93105907 A 19930416; EP 93909057 A 19930416; GB 9208428 A 19920416; JP 51814593 A 19930416; KR 19940703649 A 19941014; ZA 932648 A 19930415