EP 0636175 A1 19950201 - DECORIN FRAGMENTS AND METHODS OF INHIBITING CELL REGULATORY FACTORS.
Title (en)
DECORIN FRAGMENTS AND METHODS OF INHIBITING CELL REGULATORY FACTORS.
Title (de)
DECORIN-FRAGMENTE UND VERFAHREN ZUR ZELL-REGULATIONFAKTOREN-INHIBIERUNG.
Title (fr)
FRAGMENTS DE DECORINE ET PROCEDE D'INHIBITION DE FACTEURS DE REGULATION CELLULAIRE.
Publication
Application
Priority
- US 9303171 W 19930402
- US 86565292 A 19920403
Abstract (en)
[origin: WO9320202A1] The present invention provides a method of inhibiting an activity of a cell regulatory factor comprising contacting the cell regulatory factor with a purified polypeptide, wherein the polypeptide comprises a cell regulatory factor binding domain of a protein. The protein is characterized by a leucine-rich repeat of about 24 amino acids. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, and more specifically to active fragments of decorin or its functional equivalents to bind TGF beta . The invention also provides a cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and effect the activity of cell regulatory factors.
IPC 1-7
C12N 15/12; C07K 14/00; C07K 7/06; C07K 7/08; G01N 33/53; A61K 38/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/22 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/495 (2006.01); C07K 14/52 (2006.01); C07K 14/71 (2006.01); C07K 19/00 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C07K 14/4725 (2013.01); C07K 14/71 (2013.01); A61K 38/00 (2013.01); C07K 2319/24 (2013.01); C07K 2319/50 (2013.01); C07K 2319/73 (2013.01)
Citation (search report)
See references of WO 9320202A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9320202 A1 19931014; AU 4025793 A 19931108; AU 679178 B2 19970626; CA 2132859 A1 19931014; EP 0636175 A1 19950201; FI 944575 A0 19940930; FI 944575 A 19941129; JP H07508403 A 19950921; NO 943654 D0 19940930; NO 943654 L 19941205
DOCDB simple family (application)
US 9303171 W 19930402; AU 4025793 A 19930402; CA 2132859 A 19930402; EP 93909477 A 19930402; FI 944575 A 19940930; JP 51775293 A 19930402; NO 943654 A 19940930