EP 0637333 A1 19950208 - IFN RECEPTORS RECOGNITION FACTORS, PROTEIN SEQUENCES AND METHODS OF USE THEREOF.
Title (en)
IFN RECEPTORS RECOGNITION FACTORS, PROTEIN SEQUENCES AND METHODS OF USE THEREOF.
Title (de)
IFN-REZEPTOR ERKENNENDE FAKTOREN, PROTEINSEQUENZEN UND METHODEN IHRER VERWENDUNG.
Title (fr)
FACTEURS DE RECONNAISSANCE DE RECEPTEURS D'INTERFERON, SEQUENCES DE PROTEINES ET LEURS PROCEDES D'UTILISATION.
Publication
Application
Priority
- US 9302569 W 19930319
- US 85429692 A 19920319
- US 98049892 A 19921123
Abstract (en)
[origin: WO9319179A1] Receptor recognition factors exist that recognize the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN alpha and IFN gamma . Specific DNA sequences have been prepared that correspond to polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
IPC 1-7
C12N 15/12; C07K 14/00; C12P 21/08; C12N 15/11; C12N 9/00; C12N 1/21; C12N 5/10; G01N 33/68
IPC 8 full level
G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61K 38/21 (2006.01); A61K 39/395 (2006.01); A61K 49/00 (2006.01); A61P 1/16 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/52 (2006.01); C07K 14/555 (2006.01); C07K 14/56 (2006.01); C07K 14/57 (2006.01); C07K 16/00 (2006.01); C07K 19/00 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP)
A61K 38/21 (2013.01); A61P 1/16 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); C07K 14/4705 (2013.01)
C-Set (source: EP)
Citation (search report)
See references of WO 9319179A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9319179 A1 19930930; AU 3926893 A 19931021; CA 2132317 A1 19930930; EP 0637333 A1 19950208; JP H07505524 A 19950622
DOCDB simple family (application)
US 9302569 W 19930319; AU 3926893 A 19930319; CA 2132317 A 19930319; EP 93908447 A 19930319; JP 51676193 A 19930319