EP 0637379 A4 19960508 - NITRIC OXIDE SENSOR.
Title (en)
NITRIC OXIDE SENSOR.
Title (de)
SENSOR FÜR STICKSTOFFOXYDE.
Title (fr)
DETECTEUR D'OXYDE NITRIQUE.
Publication
Application
Priority
- US 87146392 A 19920421
- US 9303701 W 19930416
Abstract (en)
[origin: WO9321518A1] A nitric oxide (NO) microsensor (34) based on catalytic oxidation of NO comprises a thermally-sharpened carbon fiber with a tip diameter of about 0.5-0.7 mu m coated with several layers of p-type semiconducting polymeric porphyrin and cationic exchanger deposited thereon. The microsensor (34) which can be operated in either the amperometric voltametric or coulometric mode utilizing a two or three electrode system, is characterized by a liner response up to about 300 mu M, a response time better than 10 msec and a detection limit of about 10 nM. The sensor (34) of the present invention also discriminates against nitrite, the most problematic interferant in NO measurements. The amount of NO released from a single cell can thus be selectively measured in situ by a porphyrinic microsensor (34) of the invention. A larger scale sensor (12) utilizing porphyrin and cationic exchanger deposited on larger fibers or wires, platinum mesh or tin indium oxide layered on glass, can also be employed when measurement of NO concentration in chemical media, tissue or cell culture is desired.
IPC 1-7
IPC 8 full level
B01J 31/18 (2006.01); G01N 27/30 (2006.01); G01N 27/416 (2006.01); G01N 33/00 (2006.01)
CPC (source: EP)
B01J 31/1815 (2013.01); G01N 27/4045 (2013.01); G01N 33/0037 (2013.01); B01J 2531/025 (2013.01); B01J 2531/842 (2013.01); B01J 2531/845 (2013.01); B01J 2531/847 (2013.01); Y02A 50/20 (2017.12)
Citation (search report)
- [XY] US 4265714 A 19810505 - NOLAN MARY E, et al
- [X] GB 2228327 A 19900822 - MATSUSHITA ELECTRIC WORKS LTD [JP]
- [X] GB 2180653 A 19870401 - LICENTIA GMBH
- [E] WO 9402845 A1 19940203 - US HEALTH [US], et al
- [A] US 4662996 A 19870505 - VENKATASETTY H V [US]
- [Y] PATENT ABSTRACTS OF JAPAN vol. 013, no. 406 (P - 930) 8 September 1989 (1989-09-08)
- [Y] PATENT ABSTRACTS OF JAPAN vol. 009, no. 177 (P - 375) 23 July 1985 (1985-07-23)
- See references of WO 9321518A1
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 9321518 A1 19931028; AU 4032793 A 19931118; CA 2133994 A1 19931028; EP 0637379 A1 19950208; EP 0637379 A4 19960508
DOCDB simple family (application)
US 9303701 W 19930416; AU 4032793 A 19930416; CA 2133994 A 19930416; EP 93909598 A 19930416