EP 0638081 A1 19950215 - DELTA OPIOID RECEPTOR-SELECTIVE BENZYLIDENE-SUBSTITUTED MORPHINANS FOR THE TREATMENT OF ALCOHOL ABUSE.
Title (en)
DELTA OPIOID RECEPTOR-SELECTIVE BENZYLIDENE-SUBSTITUTED MORPHINANS FOR THE TREATMENT OF ALCOHOL ABUSE.
Title (de)
BENZYLIDEN-SUBSTITUIERTE MORPHINANE, SELEKTIV FÜR DELTA OPIOID REZEPTOR, ZUR BEHANDELUNG VON ALKOHOLMISSBRAUCH.
Title (fr)
MORPHINANES SUBSTITUES PAR BENZYLIDENE SELECTIFS PAR RAPPORT AUX RECEPTEURS OPIOIDES DELTA POUR LE TRAITEMENT DE L'ALCOOLISME.
Publication
Application
Priority
- US 9303221 W 19930405
- US 86799792 A 19920413
Abstract (en)
[origin: WO9321188A1] A delta-selective opioid receptor antagonist is provided of formula (I) wherein R<1> is (C1-C5)alkyl, C3-C6(cycloalkyl)alkyl, C5-C7(cycloalkenyl)alkyl, aryl, aralkyl, trans(C4-C5)alkenyl, allyl or furan-2-ylalkyl, R<2> is H, OH or O2C(C1-C5)alkyl; R<3> is H, (C1-C5)alkyl; or ((C1-C5)alkyl)C=O; and R<4> and R<5> are individually H, F, Cl, Br, NH2, NO2, (C1-C5)alkyl or (C1-C5)alkoxy, or R<4> and R<5> together are benzo or dioxymethylene; and the pharmaceutically acceptable salts thereof.
IPC 1-7
IPC 8 full level
C07D 489/02 (2006.01); A61K 31/485 (2006.01); A61P 25/30 (2006.01); C07D 489/08 (2006.01)
CPC (source: EP)
A61K 31/485 (2013.01); A61P 25/30 (2017.12); C07D 489/08 (2013.01)
Citation (search report)
See references of WO 9321188A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9321188 A1 19931028; AU 3945793 A 19931118; EP 0638081 A1 19950215; JP H07505655 A 19950622
DOCDB simple family (application)
US 9303221 W 19930405; AU 3945793 A 19930405; EP 93908747 A 19930405; JP 51843093 A 19930405