EP 0638085 A1 19950215 - INHIBITION OF CELL ADHESION BY CHEMICALLY-DEFINED OLIGOSACCHARIDES, THEIR DERIVATIVES, MIMETICS, AND ANTIBODIES DIRECTED THERETO.
Title (en)
INHIBITION OF CELL ADHESION BY CHEMICALLY-DEFINED OLIGOSACCHARIDES, THEIR DERIVATIVES, MIMETICS, AND ANTIBODIES DIRECTED THERETO.
Title (de)
INHIBITION DER ZELLADHÄSION DURCH CHEMISCH DEFINIERTE OLIGOSACCHARIDE, IHRE DERIVATE, MIMETIKA, UND ANTIKÖRPER SPEZIFISCH DAFÜR.
Title (fr)
INHIBITION DE L'ADHERENCE CELLULAIRE PAR OLIGOSACCHARIDES DEFINIS CHIMIQUEMENT, LEURS DERIVES, DES IMITATEURS ET DES ANTICORPS.
Publication
Application
Priority
- US 9301375 W 19930219
- US 83697892 A 19920219
- US 95072092 A 19920925
- US 99690392 A 19921229
Abstract (en)
[origin: WO9317033A1] Many tumor-associated and leukocyte-associated carbohydrate antigens function as adhesion molecules, recognized by lectins (carbohydrate-protein interaction) or complementary carbohydrates (carbohydrate-carbohydrate interaction). Common structures are found in the tumor-associated and leukocyte-associated antigens. Metastatic potential of tumor cells as well as transendothelial migration of leukocytes was suppressed by agents, or combinations of agents of the groups: (a) carbohydrate antigens; (b) antibodies directed to those antigens; (c) oligosaccharide components of those antigens; (d) conjugates of the antigens or oligosaccharides; and (e) mimetics of the antigens or oligosaccharides. Disclosed are oligosaccharides and derivatives thereof which inhibit cell adhesion and aggregation mediated by P-selectin (GMP-140) and E-selectin (ELAM-1). Effective agents for those purposes include hybrid sugars comprising multiple epitopes, such as Le<x>/SLe<x>, combination of individual sugars that comprise a hybrid sugar, which may be presented on liposomes, and antibodies or combinations of antibodies directed thereto.
IPC 1-7
IPC 8 full level
A61K 39/395 (2006.01); A61K 31/70 (2006.01); A61K 47/48 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C08B 37/00 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 31/70 (2013.01); A61K 47/60 (2017.07); A61P 35/00 (2017.12); C07K 14/70564 (2013.01); C07K 16/2854 (2013.01); C07K 16/30 (2013.01); A61K 38/00 (2013.01); A61K 2039/6093 (2013.01)
Citation (search report)
See references of WO 9317033A1
Designated contracting state (EPC)
CH DE DK FR GB IE IT LI NL SE
DOCDB simple family (publication)
WO 9317033 A1 19930902; CA 2129987 A1 19930902; EP 0638085 A1 19950215; JP H07504222 A 19950511
DOCDB simple family (application)
US 9301375 W 19930219; CA 2129987 A 19930219; EP 93905988 A 19930219; JP 51492593 A 19930219