EP 0639075 A4 19930929 - SPECIFIC INHIBITION OF DIHYDROFOLATE REDUCTASE AND COMPOUNDS THEREFOR.

Title (en)

SPECIFIC INHIBITION OF DIHYDROFOLATE REDUCTASE AND COMPOUNDS THEREFOR.

Title (de)

SPEZIFISCHE HEMMUNG DER DIHYDROFOLSÄUREREDUKTASE UND WIRKSTOFFE DAFÜR.

Title (fr)

INHIBITION SPECIFIQUE DE LA DIHYDROFOLATE REDUCTASE ET COMPOSES PREVUS A CET EFFET.

Publication

EP 0639075 A4 19930929 (EN)

Application

EP 92900837 A 19911114

Priority

US 9108515 W 19911114
US 61361990 A 19901114
US 73069191 A 19910716

Abstract (en)

[origin: WO9208461A1] Compounds derived from pyrimidines having improved activity against fungi such as Pneumocystis carinii, and improved selectivity for P. carinii dihydrofolate reductase over human dihydrofolate reductase, are disclosed. P. carinii pneumonia is advantageously treated with the disclosed compounds.

IPC 1-7

A61K 31/505; C07D 239/48; C07D 487/04; C07D 451/02

IPC 8 full level

C07D 239/48 (2006.01); A61K 31/505 (2006.01); A61P 31/04 (2006.01); C07D 487/04 (2006.01)

CPC (source: EP)

A61K 31/505 (2013.01); A61P 31/04 (2017.12)

C-Set (source: EP)

Citation (search report)

[X] US 4233445 A 19801111 - LEDIG KURT W, et al
[X] US 4451466 A 19840529 - HORNE CHARLES A [US], et al
[X] US 2658897 A 19531110 - HITCHINGS GEORGE H, et al
[X] US 3671564 A 19720620 - CRESSWELL RONALD MORTON, et al
[X] US 4024145 A 19770517 - KOMPIS IVAN
[X] US 4258045 A 19810324 - POE MARTIN, et al
[X] FR 1292920 A 19620511 - WELLCOME FOUND
[X] EP 0054756 A2 19820630 - WELLCOME FOUND [GB]
[X] EP 0003212 A1 19790808 - HOFFMANN LA ROCHE [CH]
[X] FR 1090394 A 19550330 - WELLCOME FOUND
[X] DE 2617967 A1 19771103 - NORDMARK WERKE GMBH
[X] FR 2357563 A1 19780203 - AMERICAN HOME PROD [US]
[X] EP 0122580 A1 19841024 - HOFFMANN LA ROCHE [CH]
[X] LU 77268 A1 19790118
[X] LU 77269 A1 19790118
[X] DE 1720031 A1 19720803 - WELLCOME FOUND
See references of WO 9208461A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9208461 A1 19920529; AU 2202792 A 19940428; AU 657348 B2 19950309; CA 2095518 A1 19920515; EP 0639075 A1 19950222; EP 0639075 A4 19930929; IE 913974 A1 19920520; JP H07509215 A 19951012; PT 99514 A 19921030; PT 99514 B 19990430

DOCDB simple family (application)

US 9108515 W 19911114; AU 2202792 A 19920831; CA 2095518 A 19911114; EP 92900837 A 19911114; IE 397491 A 19911114; JP 50229392 A 19911114; PT 9951491 A 19911114