EP 0639984 A1 19950301 - LYOPHILIZED SOMATOTROPIN FORMULATIONS.
Title (en)
LYOPHILIZED SOMATOTROPIN FORMULATIONS.
Title (de)
GEFRIERGETROCKNETE SOMATOTROPIN ENTHALTENDE PHARMAZEUTISCHE FORMULIERUNGEN.
Title (fr)
FORMULATIONS DE SOMATOTROPINE LYOPHILISEE.
Publication
Application
Priority
- US 9303182 W 19930405
- US 86476892 A 19920407
Abstract (en)
[origin: WO9319773A1] Somatotropin solutions which remain clear for extended periods and which remain clear when subjected to mechanical agitation are prepared by mixing a lyophilized somatotropin composition containing about 1 part somatotropin per 2 to 8 parts arginine HC1 on a weight basis, wherein the pH of the composition prior to lyophilization was about 7.2 to about 8.5, and a biocompatible diluent which comprises EDTA and a nonionic surfactant. If the pH of the somatotropin composition prior to lyophilization was between 7.2 and 7.8, the diluent further comprises a buffer; otherwise the diluent optionally further can comprise a buffer or nonbuffering agent.
IPC 1-7
IPC 8 full level
A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 38/27 (2006.01); A61K 47/02 (2006.01); A61K 47/18 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2006.01); A61K 47/10 (2006.01)
CPC (source: EP US)
A61K 9/19 (2013.01 - EP); A61K 38/27 (2013.01 - EP); A61K 47/183 (2013.01 - EP US); A61K 47/10 (2013.01 - EP)
Citation (search report)
See references of WO 9319773A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9319773 A1 19931014; AU 4278393 A 19931108; CA 2133737 A1 19931014; CN 1078910 A 19931201; CN 1089249 C 20020821; EP 0639984 A1 19950301; JP H08502021 A 19960305
DOCDB simple family (application)
US 9303182 W 19930405; AU 4278393 A 19930405; CA 2133737 A 19930405; CN 93104030 A 19930406; EP 93912120 A 19930405; JP 51775693 A 19930405