EP 0641212 A4 19970521 - METHOD AND REAGENT FOR INHIBITING CANCER DEVELOPMENT.

Title (en)

METHOD AND REAGENT FOR INHIBITING CANCER DEVELOPMENT.

Title (de)

VERFAHREN UND WIRKSTOFF ZUR HEMMUNG DER KREBSENTWICKLUNG.

Title (fr)

PROCEDE ET REACTIF DESTINES A EMPECHER L'EVOLUTION DU CANCER.

Publication

EP 0641212 A4 19970521 (EN)

Application

EP 93911311 A 19930513

Priority

US 9304573 W 19930513
US 88282292 A 19920514
US 88288592 A 19920514
US 93611092 A 19920826
US 93642192 A 19920826
US 93642292 A 19920826
US 93653192 A 19920826
US 93653292 A 19920826
US 98713192 A 19921207
US 612293 A 19930119
US 891093 A 19930119

Abstract (en)

[origin: WO9323057A1] An enzymatic RNA molecule which specifically cleaves mRNA encoded by an mdr-1 gene, or associated with development or maintenance of chronic myelogenous leukemia, promyelocytic leukemia, Burkitt's lymphoma or acute lymphocytic leukemia, follicular lymphoma, B-cell acute lymphocytic leukemia, breast cancer, colon carcinoma, neuroblastoma, and lung cancer.

IPC 1-7

A61K 31/70; C07H 19/10; C12N 5/16; C12N 15/63

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61P 31/12 (2006.01); C07H 19/10 (2006.01); C07H 21/02 (2006.01); C12N 5/16 (2006.01); C12N 15/113 (2010.01); C12N 15/63 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 31/12 (2017.12); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); C12N 15/1138 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01); C12N 2310/122 (2013.01); C12N 2310/123 (2013.01); C12N 2310/124 (2013.01); C12N 2310/126 (2013.01); C12N 2310/53 (2013.01)

Citation (search report)

[X] WO 9104324 A1 19910404 - INNOVIR LAB INC [US]
[A] EP 0387775 A1 19900919 - BOEHRINGER INGELHEIM INT [DE]
[XY] KASHANI-SABET M ET AL: "REVERSAL OF THE MALIGNANT PHENOTYPE BY AN ANTI-RAS RIBOZYME", ANTISENSE RESEARCH AND DEVELOPMENT, vol. 2, no. 1, 1992, pages 3 - 15, XP000576012
[X] STEPHENSON P ET AL: "IN VITRO CLEAVAGE OF AN N-RAS MESSENGER-LIKE RNA BY A RIBOZYME", ANTISENSE RESEARCH AND DEVELOPMENT, vol. 1, 1991, pages 261 - 268, XP000196553
[OX] HOLM, P. ET AL.: "CONSTRUCTION OF A RIBOZYME WITH CATALYTIC ACTIVITY AGAINST THE MRNA OF THE MULTIDRUG RESISTANCE-ASSOCIATED P-GLYCOPROTEIN .", PROC ANNU MEET AM ASSOC CANCER RES, (1992). VOL. 33, PP. 401. ABSTRACT 2393., XP000647577 & 83RD ANN. MEET. AM. ASSOC. CANCER RES., MAY 20-23, 1992 , SAN DIEGO, CA
[A] CHANG, E. & MILLER, P.: "Ras, an inner membrane transducer of growth stimuli", WICKSTROM, E. 'PROSPECTS FOR ANTISENSE NUCLEIC ACID THERAPY OF CANCER AND AIDS'; WILEY-LISS; 1991, pages 115 - 124, XP002027819
[PX] KOBAYASHI H ET AL: "Cleavage of human MDR1 mRNA by a hammerhead ribozyme.", FEBS LETTERS, (1993 MAR 15) 319 (1-2) 71-4., XP002027820
See references of WO 9323057A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9323057 A1 19931125; AU 4248993 A 19931213; AU 687001 B2 19980219; CA 2135499 A1 19931125; EP 0641212 A1 19950308; EP 0641212 A4 19970521; JP H08502950 A 19960402

DOCDB simple family (application)

US 9304573 W 19930513; AU 4248993 A 19930513; CA 2135499 A 19930513; EP 93911311 A 19930513; JP 50093993 A 19930513