EP 0641312 A1 19950308 - SYNTHETIC ARYL POLYAMINES AS EXCITATORY AMINO ACID NEUROTRANSMITTER ANTAGONISTS.
Title (en)
SYNTHETIC ARYL POLYAMINES AS EXCITATORY AMINO ACID NEUROTRANSMITTER ANTAGONISTS.
Title (de)
SYNTHETISCHE ARYLPOLYAMINE ALS ANTAGONISTEN VON ANREGBAREN AMINOSÄURE-NEUROTRANSMITTERN.
Title (fr)
POLYAMINES D'ARYLE SYNTHETIQUES UTILISEES COMME ANTAGONISTES DE NEUROTRANSMETTEURS D'ACIDES AMINES DE L'EXCITATION.
Publication
Application
Priority
- US 9206482 W 19920810
- US 74901491 A 19910823
Abstract (en)
[origin: WO9304036A1] Compounds having the formula R-(CH2)m-CO-R' wherein R is a 5 to 7 member carbocyclic system or an 8 to 11 member carbobicyclic system or any such system substituted with one or more of F, Cl, Br, OH, C1 to C4 alkyl, C1 to C4 alkoxy, CF3, phenyl, amino, C1 to C4 alkylamino and di(C1 to C4 alkyl)amino; m is 0 or 1; R' is -[NH(CH2)n]xNH2; each n is independently 2 to 5; and x is 1 to 6, and their pharmaceutically acceptable acid addition salts are potent excitatory amino acid neurotransmitter antagonists. These compounds are useful as mammalian psychotherapeutants, as the active ingredient in pharmaceutical compositions for treating conditions in mammals which are mediated by excitatory amino acid neurotransmitters and in the control of invertebrate pests.
IPC 1-7
C07C 233/40; A61K 31/405; C07D 213/56; C07D 209/18; C07F 17/02; A61K 31/44; A61K 31/165; A61K 31/295
IPC 8 full level
A61K 31/16 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4418 (2006.01); A61K 31/47 (2006.01); A61P 25/18 (2006.01); C07C 233/39 (2006.01); C07C 233/40 (2006.01); C07C 233/62 (2006.01); C07C 233/78 (2006.01); C07D 209/18 (2006.01); C07D 209/20 (2006.01); C07D 213/56 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 215/12 (2006.01); C07D 241/42 (2006.01); C07F 17/02 (2006.01)
CPC (source: EP)
A61P 25/18 (2017.12); C07C 233/40 (2013.01); C07D 209/18 (2013.01); C07D 213/56 (2013.01); C07F 17/02 (2013.01)
Citation (search report)
See references of WO 9304036A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9304036 A1 19930304; AU 2426392 A 19930316; BR 9206403 A 19941227; CA 2114798 A1 19930304; CN 1069969 A 19930317; CZ 39994 A3 19941116; EP 0641312 A1 19950308; FI 940833 A0 19940222; FI 940833 A 19940222; HU 9400503 D0 19940530; IL 102835 A0 19930131; JP H06505996 A 19940707; MX 9204866 A 19930401; PT 100801 A 19930930; ZA 926314 B 19940221
DOCDB simple family (application)
US 9206482 W 19920810; AU 2426392 A 19920810; BR 9206403 A 19920810; CA 2114798 A 19920810; CN 92109681 A 19920822; CS 3999492 A 19920810; EP 92916921 A 19920810; FI 940833 A 19940222; HU 9400503 A 19920810; IL 10283592 A 19920817; JP 50433193 A 19920810; MX 9204866 A 19920821; PT 10080192 A 19920821; ZA 926314 A 19920821