EP 0643706 A1 19950322 - COMPOUNDS, COMPOSITIONS AND METHODS FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES.
Title (en)
COMPOUNDS, COMPOSITIONS AND METHODS FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES.
Title (de)
VERBINDUNGEN, ZUSAMMENSETZUNGEN UND METHODEN UM BIOLOGISCH AKTIVE SUBSTANZEN ANOBERFL CHENMEMBRANE VON BIOPARTIKELN ZU BINDEN.
Title (fr)
COMPOSES, COMPOSITIONS ET PROCEDES PERMETTANT DE LIER DES SUBSTANCES BIO-ACTIVES AUX MEMBRANES DE SURFACE DE BIO-PARTICULES.
Publication
Application
Priority
- US 9210076 W 19921124
- US 79893691 A 19911127
- US 88443292 A 19920515
Abstract (en)
[origin: WO9311120A1] Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective delivery of therapeutic agents, and retention thereof at the selected site. Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian cancer; and (4) psoriasis.
IPC 1-7
C07D 263/62; C07D 293/00; C07D 277/62; C07D 209/02; C07D 209/04; C07K 17/02; C08B 37/10; A61K 51/00; A61K 47/48
IPC 8 full level
A61K 47/30 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61K 51/00 (2006.01); A61K 51/04 (2006.01); A61K 51/08 (2006.01); A61K 51/12 (2006.01); C07C 235/14 (2006.01); C07D 209/10 (2006.01); C07D 209/24 (2006.01); C07D 219/02 (2006.01); C07D 263/56 (2006.01); C07D 277/64 (2006.01); C07D 403/12 (2006.01); C07D 495/04 (2006.01); C07K 7/06 (2006.01); C07K 17/02 (2006.01); C08B 37/00 (2006.01); C08B 37/10 (2006.01); C09B 15/00 (2006.01); C09B 23/00 (2006.01)
CPC (source: EP)
A61K 47/6901 (2017.07); A61K 51/0453 (2013.01); A61K 51/0497 (2013.01); A61K 51/08 (2013.01); A61K 51/1258 (2013.01); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 35/00 (2017.12); C08B 37/0075 (2013.01); A61K 2121/00 (2013.01); A61K 2123/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI LU NL SE
DOCDB simple family (publication)
WO 9311120 A1 19930610; AU 1991497 A 19970710; AU 3221993 A 19930628; CA 2124329 A1 19930610; CA 2124329 C 20081118; CN 1074911 A 19930804; EP 0643706 A1 19950322; EP 0643706 A4 19941227; IL 103874 A0 19930404; JP 2003026657 A 20030129; JP 3682974 B2 20050817; JP 4095847 B2 20080604; JP H08502719 A 19960326; MX 9206844 A 19930701; NZ 245271 A 19960326; PH 31676 A 19990118
DOCDB simple family (application)
US 9210076 W 19921124; AU 1991497 A 19970430; AU 3221993 A 19921124; CA 2124329 A 19921124; CN 92115176 A 19921126; EP 93900600 A 19921124; IL 10387492 A 19921125; JP 2002192417 A 20020701; JP 51019093 A 19921124; MX 9206844 A 19921127; NZ 24527192 A 19921125; PH 45327 A 19921126