Global Patent Index - EP 0643768 A4

EP 0643768 A4 19961127 - OLIGONUCLEOTIDE SEQUENCES AND TRANSGENIC ANIMALS TRANSFECTED THEREWITH HAVING REDUCED SENSITIVITY TO NARCOTIC ANALGESICS.

Title (en)

OLIGONUCLEOTIDE SEQUENCES AND TRANSGENIC ANIMALS TRANSFECTED THEREWITH HAVING REDUCED SENSITIVITY TO NARCOTIC ANALGESICS.

Title (de)

OLIGONUKLEOTIDSEQUENZEN UND TRANSGENE TIERE DIE DAMIT TRANSFEKTIERT WURDEN BESITZEN EINE REDUZIERTE SENSITIVITÄT GEGEN NARKKOTISCHE ANALGETIKA.

Title (fr)

SEQUENCES D'OLIGONUCLEOTIDES ET ANIMAUX TRANSGENIQUES TRANSFECTES AVEC CELLES-CI ET PRESENTANT UNE SENSIBILITE REDUITE AUX ANALGESIQUES NARCOTIQUES.

Publication

EP 0643768 A4 19961127 (EN)

Application

EP 93912092 A 19930329

Priority

  • US 9302913 W 19930329
  • US 86667792 A 19920410

Abstract (en)

[origin: WO9321309A1] Clones (SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3) have been isolated and sequenced. An antisense construct has been made from part of SEQ ID NO:1 that blocks opioid binding in cells and has been used to produce transgenic animals having a reduced sensitivity to narcotic analgesics. The oligonucleotide sequence introduced into the animals at an embryonic stage was the first about 500 base pairs, but was reversed in direction. Oligonucleotide constructs of the invention are also useful as probes or as therapeutic and diagnostic agents.

IPC 1-7

C12N 15/00; C07H 15/12; C07H 17/00; A61K 31/70

IPC 8 full level

A01K 67/027 (2006.01); C07H 21/04 (2006.01); C07K 14/705 (2006.01); C12N 15/09 (2006.01); C12N 15/113 (2010.01); C12N 15/85 (2006.01)

CPC (source: EP)

A01K 67/0275 (2013.01); C07K 14/70503 (2013.01); C12N 15/1138 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01)

Citation (search report)

  • [PA] LIPPMAN, D.A. ET AL.: "Opioid-binding cell adhesion molecule (OBCAM)-related clones from a rat brain cDNA library", GENE, vol. 117, no. 2, 15 August 1992 (1992-08-15), AMSTERDAM NL, pages 249 - 254, XP000602047
  • [PX] ANN D.K. ET AL.: "Specific reduction of delta opioid receptor binding in transfected NG108-15 cells", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 267, no. 11, 15 April 1992 (1992-04-15), MD US, pages 7921 - 7926, XP000602135
  • [PX] LANE, C.M. ET AL.: "Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta opioid receptors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, no. 23, 1 December 1992 (1992-12-01), WASHINGTON US, pages 11234 - 11238, XP000602145
  • [T] GOVITRAPONG, P. ET AL.: "Transfection of NG108-15 cells with antisense opioid-binding cell adhesion molecule cDNA alters opioid receptor G-protein interaction", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 268, no. 24, 25 August 1993 (1993-08-25), MD US, pages 18280 - 18285, XP000602144
  • [T] CHAKRABORTI, A. ET AL.: "Genetic mapping of opioid binding protein gene(s) to mouse chromosome 9", MAMMALIAN GENOME, vol. 4, no. 3, 1993, pages 179 - 182, XP000602417
  • See references of WO 9321309A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9321309 A1 19931028; AU 4276993 A 19931118; AU 677200 B2 19970417; CA 2117756 A1 19931028; EP 0643768 A1 19950322; EP 0643768 A4 19961127; JP H08501442 A 19960220; NO 943808 D0 19941007; NO 943808 L 19941206

DOCDB simple family (application)

US 9302913 W 19930329; AU 4276993 A 19930329; CA 2117756 A 19930329; EP 93912092 A 19930329; JP 51836493 A 19930329; NO 943808 A 19941007