EP 0644756 A4 19960228 - SYSTEM FOR CONTROLLED RELEASE OF ANTIARRHYTHMIC AGENTS.
Title (en)
SYSTEM FOR CONTROLLED RELEASE OF ANTIARRHYTHMIC AGENTS.
Title (de)
SYSTEM ZUR KONTROLLIERTEN FREISETZUNG VON ANTIARRHYTHMISCHEN WIRKSTOFFEN.
Title (fr)
SYSTEME DE LIBERATION CONTROLEE D'AGENTS ANTIARYTHMIQUES.
Publication
Application
Priority
- US 9402838 W 19940315
- US 3330793 A 19930315
Abstract (en)
[origin: WO9421237A1] A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric patch (30) with an incorporated therapeutic agent for direct placement at the epicardium of heart (31). The dosage form is fabricated so as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, ibutilide, a potent, but toxic, Class III antiarrhythmic agent, is incorporated in polyurethane and solvent-cast to form a monolithic drug delivery device which can be co-implanted with an implantable cardiac defibrillator. Advantageously, very low doses of ibutilide administered directly to the epicardium in this manner produces a reduction in defibrillation threshold.
IPC 1-7
IPC 8 full level
A61N 1/36 (2006.01); A61K 9/00 (2006.01); A61K 9/22 (2006.01); A61L 31/16 (2006.01); A61N 1/362 (2006.01); A61N 1/39 (2006.01); A61P 9/06 (2006.01)
CPC (source: EP KR US)
A61K 9/0024 (2013.01 - EP KR US); A61L 31/16 (2013.01 - EP KR); A61N 1/362 (2013.01 - KR); A61N 1/3629 (2017.07 - EP US); A61N 1/3956 (2013.01 - EP KR); A61P 9/06 (2017.12 - EP); A61L 2300/40 (2013.01 - EP KR); A61L 2300/602 (2013.01 - EP KR)
Citation (search report)
- [Y] WO 9217240 A1 19921015 - MEDTRONIC INC [US]
- See references of WO 9421237A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9421237 A1 19940929; AU 6446794 A 19941011; CA 2135767 A1 19940929; EP 0644756 A1 19950329; EP 0644756 A4 19960228; JP H07509735 A 19951026; KR 950702101 A 19950619; NZ 263685 A 19970822
DOCDB simple family (application)
US 9402838 W 19940315; AU 6446794 A 19940315; CA 2135767 A 19940315; EP 94912237 A 19940315; JP 52120894 A 19940315; KR 19940704073 A 19941115; NZ 26368594 A 19940315