EP 0644769 A1 19950329 - BIOLOGICALLY ACTIVE PEPTIDES HAVING N-TERMINAL SUBSTITUTIONS.
Title (en)
BIOLOGICALLY ACTIVE PEPTIDES HAVING N-TERMINAL SUBSTITUTIONS.
Title (de)
BIOLOGISCH AKTIVE PEPTIDE MIT N-TERMINALEN SUBSTITUTIONEN.
Title (fr)
PEPTIDES BIOLOGIQUEMENT ACTIFS PRESENTANT DES SUBSTITUTIONS N-TERMINALES.
Publication
Application
Priority
- US 9305192 W 19930527
- US 89120192 A 19920601
Abstract (en)
[origin: WO9324138A1] An N-terminal substituted peptide or protein having formula (a). X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is (b), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 31/12 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/435 (2006.01); C07K 14/46 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C07K 7/08 (2013.01); C07K 14/001 (2013.01); C07K 14/435 (2013.01); C07K 14/46 (2013.01); C07K 14/463 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9324138 A1 19931209; AU 4525893 A 19931230; AU 674525 B2 19970102; CA 2137087 A1 19931209; EP 0644769 A1 19950329; EP 0644769 A4 19950809; JP H08500818 A 19960130
DOCDB simple family (application)
US 9305192 W 19930527; AU 4525893 A 19930527; CA 2137087 A 19930527; EP 93915173 A 19930527; JP 50083294 A 19930527