EP 0644769 A4 19950809 - BIOLOGICALLY ACTIVE PEPTIDES HAVING N-TERMINAL SUBSTITUTIONS.
Title (en)
BIOLOGICALLY ACTIVE PEPTIDES HAVING N-TERMINAL SUBSTITUTIONS.
Title (de)
BIOLOGISCH AKTIVE PEPTIDE MIT N-TERMINALEN SUBSTITUTIONEN.
Title (fr)
PEPTIDES BIOLOGIQUEMENT ACTIFS PRESENTANT DES SUBSTITUTIONS N-TERMINALES.
Publication
Application
Priority
- US 9305192 W 19930527
- US 89120192 A 19920601
Abstract (en)
[origin: WO9324138A1] An N-terminal substituted peptide or protein having formula (a). X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is (b), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 31/12 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/435 (2006.01); C07K 14/46 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C07K 7/08 (2013.01); C07K 14/001 (2013.01); C07K 14/435 (2013.01); C07K 14/46 (2013.01); C07K 14/463 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [PX] WO 9305802 A1 19930401 - MAGAININ PHARMA [US]
- [PX] WO 9222317 A1 19921223 - MAGAININ PHARMA [US]
- [A] WO 9201462 A1 19920206 - SCRIPPS RESEARCH INST [US]
- See references of WO 9324138A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9324138 A1 19931209; AU 4525893 A 19931230; AU 674525 B2 19970102; CA 2137087 A1 19931209; EP 0644769 A1 19950329; EP 0644769 A4 19950809; JP H08500818 A 19960130
DOCDB simple family (application)
US 9305192 W 19930527; AU 4525893 A 19930527; CA 2137087 A 19930527; EP 93915173 A 19930527; JP 50083294 A 19930527