EP 0644946 A4 19970312 - VECTOR PARTICLES RESISTANT TO INACTIVATION BY HUMAN SERUM.
Title (en)
VECTOR PARTICLES RESISTANT TO INACTIVATION BY HUMAN SERUM.
Title (de)
GEGEN DIE INAKTIVIERUNG DURCH MENSCHLICHES SERUM RESISTENTE VEKTORPARTIKEL.
Title (fr)
PARTICULES VECTEURS RESISTANTES A L'INACTIVATION PAR LE SERUM HUMAIN.
Publication
Application
Priority
- US 9304706 W 19930514
- US 89660392 A 19920610
Abstract (en)
[origin: WO9325698A1] A retroviral vector particle resistant to inactivation by human serum. The vector particles preferably include p15E protein wherein at least a portion of the DNA encoding p15E protein is mutated such that the vector particle is resistant to inactivation by human serum. The vector particles may further include a protein containing a receptor binding region which binds to the receptor of a human target cell, thereby enabling the direct introduction of desired heterologous genes in vivo, whereby the vector particle including the heterologous gene travels directly to a targeted cell or tissue.
IPC 1-7
C12P 21/06; C12N 15/00; C12N 7/00; C12N 5/00; C07K 1/00; C07K 14/00; C07K 15/00
IPC 8 full level
C12N 15/09 (2006.01); C07K 14/15 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/867 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/005 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2740/13022 (2013.01); C12N 2740/13043 (2013.01)
Citation (search report)
- [X] WO 9119798 A1 19911226 - DANA FARBER CANCER INST INC [US]
- [X] BANAPOUR, B. ET AL.: "The Acquired Immunodeficiency Syndrome associated retrovirus is not sensitive to lysis or inactivation by human serum", VIROLOGY, vol. 152, no. 1, 1986, ORLANDO US, pages 268 - 271, XP002021491
- See references of WO 9325698A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9325698 A1 19931223; CA 2137361 A1 19931223; EP 0644946 A1 19950329; EP 0644946 A4 19970312; JP H09507741 A 19970812
DOCDB simple family (application)
US 9304706 W 19930514; CA 2137361 A 19930514; EP 93913964 A 19930514; JP 50147994 A 19930514