Global Patent Index - EP 0647139 A4

EP 0647139 A4 19970903 - ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR -i(HAEMOPHILUS INFLUENZAE).

Title (en)

ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR -i(HAEMOPHILUS INFLUENZAE).

Title (de)

KONJUGAT-IMPFSTOFF AUS ADHESIN-OLIGOSACCHARID GEGEN -i( HÄMOPHILUS IN FLUENZA).

Title (fr)

VACCIN CONJUGUE ADHESINE-OLIGOSACCHARIDE CONTRE -i(HAEMOPHILUS INFLUENZAE).

Publication

EP 0647139 A4 19970903 (EN)

Application

EP 93916717 A 19930622

Priority

  • US 9306016 W 19930622
  • US 90307992 A 19920622

Abstract (en)

[origin: CA2138765C] Disclosed herein are immunogenic polysaccharide-H. influenzae adhesin protein conjugates, a purified H. influenzae adhesin protein and related proteins and polypeptides, DNA useful for producing the proteins, synthetic polyribosylribotol phosphate (PRP) oligosaccharides and intermediates useful for their synthesis, and methods of making and using these materials. The conjugates comprise a PRP fragment, preferably a synthetic oligosaccharide, coupled to an H. influenzae adhesin protein. The invention further comprises purified H. influenzae adhesin proteins and novel PRP oligosaccharides. The invention also comprises methods of producing these materials and using them in a vaccine to protect humans and other mammals against H. influenzae infection.

IPC 1-7

A61K 39/00; A61K 38/00; C07K 15/00; C07H 15/02; C07H 1/04; C07H 13/00; C07K 1/00; C12P 17/00; C12P 21/06; C12Q 1/34

IPC 8 full level

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/102 (2006.01); A61P 31/04 (2006.01); A61P 37/04 (2006.01); C07H 1/04 (2006.01); C07H 11/04 (2006.01); C07H 13/00 (2006.01); C07H 15/02 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01); C07K 1/22 (2006.01); C07K 14/11 (2006.01); C07K 14/285 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 19/00 (2006.01); C12N 1/21 (2006.01); C12N 15/31 (2006.01); C12P 17/00 (2006.01); C12P 21/02 (2006.01); C12P 21/06 (2006.01); C12Q 1/34 (2006.01); C12R 1/19 (2006.01)

Citation (search report)

  • [AD] EP 0338265 A2 19891025 - AMERICAN CYANAMID CO [US]
  • [PX] WO 9210936 A1 19920709 - MICROCARB INC [US]
  • [XY] WEINSTEIN ET AL.: "Cloning and characterization of an Haemophilus influenzae type b adhesin.", ABSTRACTS OF THE 92ND GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 92, 26 May 1992 (1992-05-26) - 30 May 1992 (1992-05-30), NEW ORLEANS, pages 136 (D-243), XP002025486
  • [Y] CHAN L. AND JUST G.: "Synthesis of oligomers of the capsular polysaccharide of the Haemophilus influenzae type b bacteria.", TETRAHEDRON, vol. 46, no. 1, 1990, pages 151 - 162, XP002025487
  • [PX] SAMUEL J. ET AL.: "Cloning and characterization of an Haemophilus influenzae type B adhesion.", JOURNAL OF CELLULAR BIOCHEMISTRY (KEYSTONE SYMPOSIUM ON CARBOHYDRATE LIGANDS AND THEIR PROTEIN RECEPTORS), vol. S17a, 24 January 1993 (1993-01-24) - 31 January 1993 (1993-01-31), pages 378, XP000644714
  • See references of WO 9400149A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

CA 2138765 A1 19940106; CA 2138765 C 19990907; EP 0647139 A1 19950412; EP 0647139 A4 19970903; JP 2805174 B2 19980930; JP H07509693 A 19951026

DOCDB simple family (application)

CA 2138765 A 19930622; EP 93916717 A 19930622; JP 50255994 A 19930622