EP 0648223 A1 19950419 - SUBSTITUTED LACTOSE DERIVATIVES AS CELL ADHESION INHIBITORS.
Title (en)
SUBSTITUTED LACTOSE DERIVATIVES AS CELL ADHESION INHIBITORS.
Title (de)
SUBSTITUTIERTE LACTOSEDERIVATE ALS INHIBITOREN ZELLADHÄSION.
Title (fr)
DERIVES DE LACTOSE SUBSTITUES UTILISES COMME INHIBITEURS D'ADHESION CELLULAIRE.
Publication
Application
Priority
- US 9306110 W 19930625
- US 91070992 A 19920629
Abstract (en)
[origin: WO9400477A1] Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In formula (I), R1 is independently H or lower alkyl(1-4C); R2 is H, OH or lower alkyl(1-4C), alkylaryl or one or more additional saccharide residues; R3 is a negatively charged moiety including SO4--, PO4--, or related group; Y is H or lower alkyl(1-4C); and X is -CHR4(CHOR1)2CHR5OR1 wherein R4 and R5 are each independently H, lower alkyl(1-4C), or taken together result in a five- or six-membered ring optionally containing a heteroatom selected from the group consisting of O, S, and NR1; said five- or six-membered ring optionally substituted with one substituent selected from the group consisting of R1, CH2OR1, OR1, OOCR1, NR12, NHCOR1, and SR1 with the proviso that if X represents a hexose substituent R3 and R4, taken together, cannot provide a hexose substituent.
IPC 1-7
IPC 8 full level
C07H 15/04 (2006.01); A61K 31/70 (2006.01); A61K 31/7028 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07H 3/04 (2006.01); C07H 3/06 (2006.01); C07H 11/00 (2006.01); C07H 15/18 (2006.01); C07H 23/00 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 35/00 (2017.12); C07H 3/04 (2013.01); C07H 3/06 (2013.01); C07H 11/00 (2013.01); C07H 15/18 (2013.01); C07H 23/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9400477 A1 19940106; AU 4652693 A 19940124; AU 678373 B2 19970529; CA 2138645 A1 19940106; EP 0648223 A1 19950419; EP 0648223 A4 19960731; JP H08500820 A 19960130
DOCDB simple family (application)
US 9306110 W 19930625; AU 4652693 A 19930625; CA 2138645 A 19930625; EP 93916790 A 19930625; JP 50260794 A 19930625