EP 0649408 A1 19950426 - PROCESS FOR MAKING PHENYLTHIOMETHYLPYRIDINYLALKENOATES.
Title (en)
PROCESS FOR MAKING PHENYLTHIOMETHYLPYRIDINYLALKENOATES.
Title (de)
VERFAHREN ZUM HERSTELLUNG VON PHENYLTHIOMETHYLPYRIDINYLALKENOATEN.
Title (fr)
PROCEDE DE PRODUCTION DE PHENYLTHIOMETHYLPYRIDINYLALCENOATES.
Publication
Application
Priority
- US 9306177 W 19930630
- US 90695192 A 19920630
- US 2520093 A 19930302
Abstract (en)
[origin: WO9400433A1] This invention relates to a process of making a compound of formula (I) where R1 contains an (alpha),(beta)-unsaturated carbonyl group and Rn is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the presence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
[origin: WO9400433A1] This invention relates to a process of making a compound of formula (I) where R1 contains an alpha , beta -unsaturated carbonyl group and Rn is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the presence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4418 (2006.01); A61P 43/00 (2006.01); C07D 213/55 (2006.01); C07D 213/65 (2006.01)
CPC (source: EP KR)
A61P 43/00 (2017.12 - EP); C07D 213/30 (2013.01 - KR); C07D 213/55 (2013.01 - EP); C07D 213/65 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9400433 A1 19940106; AU 4655793 A 19940124; AU 678979 B2 19970619; CA 2138955 A1 19940106; CN 1095713 A 19941130; EP 0649408 A1 19950426; EP 0649408 A4 19950621; JP 3181917 B2 20010703; JP H07508283 A 19950914; KR 950702184 A 19950619; MX 9303972 A 19940429; NZ 254473 A 19961126; TW 247907 B 19950521
DOCDB simple family (application)
US 9306177 W 19930630; AU 4655793 A 19930630; CA 2138955 A 19930630; CN 93109433 A 19930630; EP 93916841 A 19930630; JP 50263894 A 19930630; KR 19940704738 A 19941224; MX 9303972 A 19930630; NZ 25447393 A 19930630; TW 82105973 A 19930727