EP 0649408 A4 19950621 - PROCESS FOR MAKING PHENYLTHIOMETHYLPYRIDINYLALKENOATES.
Title (en)
PROCESS FOR MAKING PHENYLTHIOMETHYLPYRIDINYLALKENOATES.
Title (de)
VERFAHREN ZUM HERSTELLUNG VON PHENYLTHIOMETHYLPYRIDINYLALKENOATEN.
Title (fr)
PROCEDE DE PRODUCTION DE PHENYLTHIOMETHYLPYRIDINYLALCENOATES.
Publication
Application
Priority
- US 9306177 W 19930630
- US 90695192 A 19920630
- US 2520093 A 19930302
Abstract (en)
[origin: WO9400433A1] This invention relates to a process of making a compound of formula (I) where R1 contains an (alpha),(beta)-unsaturated carbonyl group and Rn is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the presence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
[origin: WO9400433A1] This invention relates to a process of making a compound of formula (I) where R1 contains an alpha , beta -unsaturated carbonyl group and Rn is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the presence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4418 (2006.01); A61P 43/00 (2006.01); C07D 213/55 (2006.01); C07D 213/65 (2006.01)
CPC (source: EP KR)
A61P 43/00 (2017.12 - EP); C07D 213/30 (2013.01 - KR); C07D 213/55 (2013.01 - EP); C07D 213/65 (2013.01 - EP KR)
Citation (search report)
- [XD] WO 9118601 A1 19911212 - SMITHKLINE BEECHAM CORP [US]
- See references of WO 9400433A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9400433 A1 19940106; AU 4655793 A 19940124; AU 678979 B2 19970619; CA 2138955 A1 19940106; CN 1095713 A 19941130; EP 0649408 A1 19950426; EP 0649408 A4 19950621; JP 3181917 B2 20010703; JP H07508283 A 19950914; KR 950702184 A 19950619; MX 9303972 A 19940429; NZ 254473 A 19961126; TW 247907 B 19950521
DOCDB simple family (application)
US 9306177 W 19930630; AU 4655793 A 19930630; CA 2138955 A 19930630; CN 93109433 A 19930630; EP 93916841 A 19930630; JP 50263894 A 19930630; KR 19940704738 A 19941224; MX 9303972 A 19930630; NZ 25447393 A 19930630; TW 82105973 A 19930727