EP 0650367 A1 19950503 - BLOCKING INTERCELLULAR INTERACTIONS WITH CD43 CHIMERIC MOLECULES.
Title (en)
BLOCKING INTERCELLULAR INTERACTIONS WITH CD43 CHIMERIC MOLECULES.
Title (de)
VERHINDERUNG INTERZELLULÄRER WECHSELWIRKUNGEN MIT CHIMÄREN CD43-MOLEKÜLEN.
Title (fr)
BLOCAGE DES INTERACTIONS INTERCELLULAIRES AVEC DES MOLECULES CHIMERIQUES CD43.
Publication
Application
Priority
- US 9304517 W 19930513
- US 89157192 A 19920601
Abstract (en)
[origin: WO9400143A1] Disclosed is a method of inhibiting an interaction between a first and a second cell in a mammal. The method involves providing a soluble chimeric molecule which includes: a) a cell targeting molecule which is capable of specifically recognizing and binding to a molecule on the surface of the first cell covalently bonded to b) a CD43 extracellular domain bearing a net negative charge at physiological pH; and administering the chimeric molecule to the mammal to inhibit the intercellular interaction. Also disclosed are useful CD43-containing chimeric molecules.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61P 29/00 (2006.01); C07K 14/705 (2006.01); C07K 14/73 (2006.01); C07K 14/78 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12P 21/02 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); C07K 14/70514 (2013.01); C07K 14/70525 (2013.01); C07K 14/70542 (2013.01); C07K 14/70553 (2013.01); C07K 14/70564 (2013.01); C07K 14/70596 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); Y02A 50/30 (2017.12)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9400143 A1 19940106; EP 0650367 A1 19950503; EP 0650367 A4 19980415; JP H07507278 A 19950810
DOCDB simple family (application)
US 9304517 W 19930513; EP 93913851 A 19930513; JP 51968393 A 19930513