Global Patent Index - EP 0650367 A4

EP 0650367 A4 19980415 - BLOCKING INTERCELLULAR INTERACTIONS WITH CD43 CHIMERIC MOLECULES.

Title (en)

BLOCKING INTERCELLULAR INTERACTIONS WITH CD43 CHIMERIC MOLECULES.

Title (de)

VERHINDERUNG INTERZELLULÄRER WECHSELWIRKUNGEN MIT CHIMÄREN CD43-MOLEKÜLEN.

Title (fr)

BLOCAGE DES INTERACTIONS INTERCELLULAIRES AVEC DES MOLECULES CHIMERIQUES CD43.

Publication

EP 0650367 A4 19980415 (EN)

Application

EP 93913851 A 19930513

Priority

  • US 9304517 W 19930513
  • US 89157192 A 19920601

Abstract (en)

[origin: WO9400143A1] Disclosed is a method of inhibiting an interaction between a first and a second cell in a mammal. The method involves providing a soluble chimeric molecule which includes: a) a cell targeting molecule which is capable of specifically recognizing and binding to a molecule on the surface of the first cell covalently bonded to b) a CD43 extracellular domain bearing a net negative charge at physiological pH; and administering the chimeric molecule to the mammal to inhibit the intercellular interaction. Also disclosed are useful CD43-containing chimeric molecules.

IPC 1-7

A61K 38/00; C12P 21/06; C12N 15/00; C07K 14/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61P 29/00 (2006.01); C07K 14/705 (2006.01); C07K 14/73 (2006.01); C07K 14/78 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12P 21/02 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 29/00 (2017.12); C07K 14/70514 (2013.01); C07K 14/70525 (2013.01); C07K 14/70542 (2013.01); C07K 14/70553 (2013.01); C07K 14/70564 (2013.01); C07K 14/70596 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); Y02A 50/30 (2017.12)

Citation (search report)

  • [Y] WO 9205188 A1 19920402 - BIOGEN INC [US]
  • [A] EP 0391088 A2 19901010 - BLOOD RES LAB CENTER [US]
  • [Y] SHELLEY ET AL.: "MOLECULAR CHARACTERIZATION OF SIALOPHORIN (CD43), THE LYMPHOCYTE SURFACE SIALOGLYCOPROTEIN DEFECTIVE IN WISKOTT-ALDRICH SYNDROME", PNAS, vol. 86, 1989, pages 2819 - 2823, XP002052839
  • [A] STOOLMAN: "ADHESION MOLECULES CONTROLLING LYMPHOCYTE MIGRATION", CELL, vol. 56, 1989, pages 907 - 910, XP002052840
  • [A] STAUNTON ET AL.: "THE ARRANGEMENT OF THE IMMUNOGLOBULIN-LIKE DOMAINS OF ICAM-1 AND THE BINDING SITES FOR LFA-1 AND RHINOVIRUS", CELL, vol. 61, April 1990 (1990-04-01), pages 243 - 254, XP002052841
  • See references of WO 9400143A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9400143 A1 19940106; EP 0650367 A1 19950503; EP 0650367 A4 19980415; JP H07507278 A 19950810

DOCDB simple family (application)

US 9304517 W 19930513; EP 93913851 A 19930513; JP 51968393 A 19930513