EP 0650526 A4 19980204 - FORMATION OF TRIPLE HELIX COMPLEXES OF SINGLE STRANDED NUCLEIC ACIDS USING NUCLEOSIDE OLIGOMERS.
Title (en)
FORMATION OF TRIPLE HELIX COMPLEXES OF SINGLE STRANDED NUCLEIC ACIDS USING NUCLEOSIDE OLIGOMERS.
Title (de)
HERSTELLUNG VON TRIPLE-HELIX-KOMPLEXEN AUS EINZELSTRÄNGIGEM NUKLEINSÄUREN DURCH BENUTZUNG VON NUKLEOTIDOLIGOMEREN.
Title (fr)
FORMATION DE COMPLEXES A TRIPLE HELICE D'ACIDES NUCLEIQUES MONOBRIN A L'AIDE D'OLIGOMERES DE NUCLEOSIDE.
Publication
Application
Priority
- US 9208458 W 19921005
- US 77208191 A 19911007
Abstract (en)
[origin: WO9307295A1] A specific segment of single stranded nucleic acid may be detected or recognized by formation of a triple helix structure using first and second oligomers comprised of nucleosidyl units linked by internucleosidyl phosphorus linkages. Function or expression of single stranded nucleic acid segments may be prevented by triple helix formation. Novel oligomers comprising modified nucleosidyl units are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C07H 21/00 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01)
CPC (source: EP)
C07H 21/00 (2013.01); C12N 15/113 (2013.01); C12Q 1/6839 (2013.01); C12N 2310/15 (2013.01); C12N 2310/152 (2013.01); C12N 2310/3125 (2013.01); C12N 2310/321 (2013.01); C12N 2310/334 (2013.01); C12N 2310/3511 (2013.01); C12N 2310/3521 (2013.01)
Citation (search report)
- [X] WO 9015884 A1 19901227 - UNIV JOHNS HOPKINS [US]
- [PX] WO 9210590 A1 19920625 - GILEAD SCIENCES INC [US]
- [X] HÉLÈNE C: "The anti-gene strategy: Control of gene expression by triplex-forming-oligonucleotides", ANTI-CANCER DRUG DESIGN, vol. 6, 1991, pages 569 - 584, XP002047547
- [X] WELLS RD ET AL: "The chemistry and biology of unusual DNA structures adopted by oligopurine-oligopyrimidine sequences", FASEB JOURNAL, vol. 2, 1988, pages 2939 - 2949, XP002047548
- [X] ONO A ET AL: "Triplex formation of oligonucleotides containing 2'-O-methylpseudoisocytidine in substitution for 2'-deoxycitidine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 113, 1991, pages 4032 - 4033, XP002047549
- [PX] JAYASENA S D ET AL: "OLIGONUCLEOTIDE-DIRECTED TRIPLE HELIX FORMATION AT ADJACENT OLIGOPURINE AND OLIGOPYRIMIDINE DNA TRACTS BY ALTERNATE STRAND RECOGNITION", NUCLEIC ACIDS RESEARCH, vol. 20, no. 20, 1 January 1992 (1992-01-01), pages 5279 - 5288, XP002000132
- See references of WO 9307295A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9307295 A1 19930415; AU 2488197 A 19970904; AU 2785292 A 19930503; CA 2119890 A1 19930415; EP 0650526 A1 19950503; EP 0650526 A4 19980204; IL 103311 A0 19930315; JP H07501936 A 19950302; NZ 244606 A 19970727
DOCDB simple family (application)
US 9208458 W 19921005; AU 2488197 A 19970613; AU 2785292 A 19921005; CA 2119890 A 19921005; EP 92921942 A 19921005; IL 10331192 A 19921001; JP 50711393 A 19921005; NZ 24460692 A 19921002