Global Patent Index - EP 0650596 A4

EP 0650596 A4 19960124 - COMPOSITIONS AND METHODS FOR REGULATING CELLULAR SIGNAL TRANSDUCING SYSTEMS.

Title (en)

COMPOSITIONS AND METHODS FOR REGULATING CELLULAR SIGNAL TRANSDUCING SYSTEMS.

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR REGULIERUNG ZELLULÄRER SIGNALÜBERTRAGUNGSSYSTEME.

Title (fr)

COMPOSITIONS ET PROCEDES DE REGULATION DE SYSTEMES DE TRANSDUCTION DE SIGNAUX CELLULAIRES.

Publication

EP 0650596 A4 19960124 (EN)

Application

EP 92917394 A 19920330

Priority

  • US 9202632 W 19920330
  • US 85884192 A 19920327

Abstract (en)

[origin: WO9320439A1] Disclosed is a method of regulating the metabolic pathway of inositol in a cell. This method includes the introduction into said cell of a molecule which is then allowed to couple a membrane-bound receptor, activatable by an external signal, to an intracellular phosphodiesterase of the type responsible for generating second messenger substance, IP3. This molecule is selected from the group consisting of a purified A-protein, and active fragments, active analogs, and active fusion products thereof. Also disclosed are methods of detecting an A-protein and methods of inhibiting the growth and proliferation of cancer cells using anti-A-protein antibodies.

IPC 1-7

G01N 33/53; C07K 7/08; C07K 14/00; A61K 38/00; A61K 39/395

IPC 8 full level

G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61P 3/00 (2006.01); A61P 35/00 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 9/16 (2006.01); C12N 15/02 (2006.01); C12P 21/08 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61K 47/62 (2017.07); A61P 3/00 (2017.12); A61P 35/00 (2017.12); C07K 14/4722 (2013.01); C07K 16/18 (2013.01); G01N 33/57484 (2013.01); G01N 33/6872 (2013.01); G01N 33/6893 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [DX] SCHMIDT ET AL: "A-PROTEIN CATALYSES THE ADP-RIBOSYLATION OF G-PROTEIN FROM COW ROD OUTER SEGMENTS", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 29, 15 October 1987 (1987-10-15), pages 14333 - 14336
  • [X] SCHMIDT ET AL: "ACTIVATION OF MEMBRANE-BOUND AND SOLUBLE A-PROTEIN IN THE BOVINE ROD OUTER SEGMENT", INVEST.OPHTHALMOL.VISUAL SCI., vol. 30, no. S3, pages 172
  • [X] SCHMIDT ET AL: "A-PROTEIN:COFACTOR FOR CHOLERA TOXIN-DEPENDENT ADP-RIBOSYLATION OF G-PROTEIN IN BOVINE ROS", INVEST.OPHTHALMOL.VISUAL SCI., vol. 27, no. S3, pages 216
  • [X] SCHMIDT ET AL: "INHIBITION OF PIP2 HYDROLYSIS BY MONOCLONAL ANTIBODIES RAISED AGAINST BOVINE ROS A-PROTEIN", INVEST.OPHTHALMOL.VISUAL SCI., vol. 31, no. 4 ABS.ISSUE, pages 581
  • See references of WO 9320439A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9320439 A1 19931014; AU 1873592 A 19931108; CA 2132624 A1 19931014; EP 0650596 A1 19950503; EP 0650596 A4 19960124; JP H07507537 A 19950824

DOCDB simple family (application)

US 9202632 W 19920330; AU 1873592 A 19920330; CA 2132624 A 19920330; EP 92917394 A 19920330; JP 51023592 A 19920330