EP 0651745 A1 19950510 - NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS.
Title (en)
NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS.
Title (de)
NEUE PYRIDIN-DERIVATIVE MIT LEUKOTRIEN B 4?-ANTAGONISTISCHER WIRKUNG.
Title (fr)
NOUVEAUX DERIVES DE PYRIDINE A EFFET ANTAGONISTE CONTRE LES LEUCOTRIENES B 4?.
Publication
Application
Priority
- DE 9300593 W 19930701
- DE 4224402 A 19920721
Abstract (en)
[origin: DE4224402A1] The invention pertains to new pyridine derivatives of formula (I) where . &cir& _. &cir& _. &cir& _ denotes a single bond or a double bond, m, n, p and r in each case stands for a number from 0 to 5, q is 1 or 2, U denotes a single bond or the grouping -CH2-CH2-, -CHOH-, -CO- -CH=CH-, -C=C-, -CO-CO- or -CHOH-CHOH-, V stands for a single bond, phenyl residue or pyridyle residue, W is a hydrogen atom, a halogen atom, an alkyl group with up to four carbon atoms, a trifluoromethyl group, an alkylsulfonylamino group, a trifluoromethylsulfonylamino group, an arylsulfonylaminocarbonyl group, a free, esterified or amidated carboxyl group, or a hydroxy group, X denotes a free, esterified or amidated carboxyl group, Y is an oxygen atom or a methylene group, and Z is a single bond if q is 2 or otherwise an alkyl group or alkylene group with at most 8 carbon atoms or a phenyl, phenoxy or styryl residue substituted by alkyl groups with at most 4 carbon atoms, alkoxy groups with at most 4 carbon atoms, 1-oxoalkyl groups with at most 4 carbon atoms, halogen atoms and/or trifluoromethyl groups. The invention also concerns salts of these derivatives with bases which are generally recognized as physiologically safe.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4418 (2006.01); A61P 43/00 (2006.01); C07D 213/61 (2006.01); C07D 213/65 (2006.01); C07D 213/79 (2006.01)
CPC (source: EP US)
A61P 43/00 (2017.12 - EP); C07D 213/61 (2013.01 - EP US); C07D 213/65 (2013.01 - EP US)
Citation (search report)
See references of WO 9402464A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
DE 4224402 A1 19940127; AU 4415393 A 19940214; AU 679184 B2 19970626; CA 2139586 A1 19940203; EP 0651745 A1 19950510; HU 9500160 D0 19950328; HU T71887 A 19960228; JP H07508990 A 19951005; US 5624943 A 19970429; WO 9402464 A1 19940203
DOCDB simple family (application)
DE 4224402 A 19920721; AU 4415393 A 19930701; CA 2139586 A 19930701; DE 9300593 W 19930701; EP 93914599 A 19930701; HU 9500160 A 19930701; JP 50389094 A 19930701; US 37460895 A 19950427