EP 0651755 A1 19950510 - CEPHALOSPORINS AND 1-CARBA-1-DETHIA CEPHALOSPORINS.
Title (en)
CEPHALOSPORINS AND 1-CARBA-1-DETHIA CEPHALOSPORINS.
Title (de)
CEPHALOSPORINE UND 1-CARBA-1-DETHIACEPHALOSPORINE.
Title (fr)
CEPHALOSPORINES ET 1-CARBA-1-DETHIA CEPHALOSPORINES.
Publication
Application
Priority
- GB 9301523 W 19930723
- GB 9215631 A 19920723
Abstract (en)
[origin: WO9402489A1] A compound of formula (I) or a salt thereof, wherein: R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically acceptable salt-forming group or (in vivo) hydrolysable ester group; X is S, SO, SO2 or CH2; R4 is a bicyclic group (a), where m is 1 or 2; wherein one of Y or Z is O, S, SO or SO2 and the other is CH2, and wherein R4 may be unsubstituted or may have one or more optional substituents R5. The compounds of formula (I) have antibacterial activity. Processes for making them and formulations including them are described.
[origin: WO9402489A1] A compound of formula (I) or a salt thereof, wherein: R<1> is hydrogen, methoxy or formamido; R<2> is an acyl group; CO2R<3> is a carboxy group or a carboxylate anion, or R<3> is a readily removable carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; X is S, SO, SO2 or CH2; R<4> is a bicyclic group (a), where m is 1 or 2; wherein one of Y or Z is O, S, SO or SO2 and the other is CH2, and wherein R<4> may be unsubstituted or may have one or more optional substituents R<5>. The compounds of formula (I) have antibacterial activity. Processes for making them and formulations including them are described.
IPC 1-7
C07D 501/00; C07D 463/00; C07D 405/12; C07D 409/12; C07D 405/06; C07D 409/06; A61K 31/545; A61K 31/435
IPC 8 full level
C07D 405/06 (2006.01); A61K 31/435 (2006.01); A61K 31/545 (2006.01); A61K 31/546 (2006.01); A61P 31/04 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 463/00 (2006.01); C07D 501/00 (2006.01); C07D 501/20 (2006.01); C07D 501/57 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07D 463/22 (2013.01); C07D 501/00 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
See references of WO 9402489A1
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9402489 A1 19940203; EP 0651755 A1 19950510; GB 9215631 D0 19920909; JP H07509455 A 19951019
DOCDB simple family (application)
GB 9301523 W 19930723; EP 93917875 A 19930723; GB 9215631 A 19920723; JP 50428194 A 19930723