Global Patent Index - EP 0652765 A4

EP 0652765 A4 19970409 - DES-TYR DYNORPHIN ANALOGUES.

Title (en)

DES-TYR DYNORPHIN ANALOGUES.

Title (de)

DES-TYR DYNORPHINANALOGE.

Title (fr)

ANALOGUES DE DYNOPHINE DES-TYR.

Publication

EP 0652765 A4 19970409 (EN)

Application

EP 93914274 A 19930601

Priority

  • US 9305161 W 19930601
  • US 89792092 A 19920612

Abstract (en)

[origin: WO9325217A1] Novel peptides of the invention are dynorphin analogues and have similar activity to endogenous dynorphin, but are des-Tyr or des-Tyr-Gly with respect to endogenous dynorphin. The novel peptides have therapeutic uses, such as administration to a host tolerant to a narcotic analgesic in order to potentiate activity of the narcotic analgesic and/or to block withdrawal symptoms.

IPC 1-7

A61K 38/00; C07K 5/00; C07K 7/00; C07K 15/00; C07K 17/00

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/10 (2006.01); A61P 25/30 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/665 (2006.01)

IPC 8 main group level

A61K (2006.01)

CPC (source: EP KR)

A61K 38/00 (2013.01 - KR); A61P 25/30 (2017.12 - EP); C07K 14/665 (2013.01 - EP); C07K 17/00 (2013.01 - KR); A61K 38/00 (2013.01 - EP)

Citation (search report)

  • [E] WO 9606626 A1 19960307 - LEE NANCY M [US], et al
  • [XY] BAKSHI R. & FADEN A.I.: "Compeptitive and non-compeptitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis", BRAIN RESEARCH, vol. 507, 1990, pages 1 - 5, XP000612654
  • [XY] ROCHFORD J. ET AL.: "Intrathecal administation of dynorphin A and its fragments increase heart rate and arteria pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism", BRAIN RESEARCH, vol. 565, no. 1, 1991, pages 67 - 77, XP000612957
  • [XY] CODD E.E. ET AL.: "A non-opoid pattern characterizes inhibition of growth hormone releasing peptide binding by Dynorphin-related peptides", NEUROPEPTIDES (EDINBOURGH), vol. 15, no. 3, 1990, pages 133 - 137, XP000612963
  • [PX] MWYER M.E.: "Intrastrial injections of Dynorphin A fragments potentiate the dorsal immobility response in rats", PHARMACOL.BIOCHEM.BEHAV., vol. 44, no. 2, 1993, pages 329 - 332, XP000613059
  • [PX] TAKEMORI A. ET AL.: "Suppression by Dynorphin A and des-Tyr-Dynorphin A peptides of the expression of opiate withdrawl and tolerance in morphine-depedent mice", J.PHARMACOL.EXP.THER., vol. 266, no. 1, 1993, pages 121 - 124, XP000612554
  • [XDY] XIE, GUO-XI ET AL.: "Expression of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands", PROC.NATL.ACAD.SCI., vol. 89, 1992, USA, pages 4124 - 4128, XP002022035
  • See references of WO 9325217A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9325217 A1 19931223; AU 4399093 A 19940104; CA 2137916 A1 19931223; CZ 281630 B6 19961113; CZ 313194 A3 19950816; EP 0652765 A1 19950517; EP 0652765 A4 19970409; FI 945811 A0 19941209; FI 945811 A 19950206; HU 9403563 D0 19950228; HU T70160 A 19950928; JP H08501075 A 19960206; KR 950701818 A 19950517; NO 944778 D0 19941209; NO 944778 L 19950210; RU 95106651 A 19961227

DOCDB simple family (application)

US 9305161 W 19930601; AU 4399093 A 19930601; CA 2137916 A 19930601; CZ 313194 A 19930601; EP 93914274 A 19930601; FI 945811 A 19941209; HU 9403563 A 19930601; JP 50153794 A 19930601; KR 19940704525 A 19941212; NO 944778 A 19941209; RU 95106651 A 19950111