EP 0652863 A1 19950517 - NON-PEPTIDIC SURROGATES OF THE LDV SEQUENCE AND THEIR USE IN THE TREATMENT OF INFLAMMATION, AUTOIMMUNE DISEASES AND TUMOUR PROGRESSION.
Title (en)
NON-PEPTIDIC SURROGATES OF THE LDV SEQUENCE AND THEIR USE IN THE TREATMENT OF INFLAMMATION, AUTOIMMUNE DISEASES AND TUMOUR PROGRESSION.
Title (de)
PEPTIDOMIMETISCHE VERBINDUNGEN FÜR DIE LDV-SEQUENZ UND IHRE VERWENDUNG IN DER BEHANDLUNG VON ENTZÜNDUNGEN, AUTOIMMUN-KRANKHEITEN UND TUMOURWACHSTUM.
Title (fr)
SUCCEDANES NON PEPTIDIQUES DE LA SEQUENCE LDV ET LEUR UTILISATION DANS LE TRAITEMENT D'INFLAMMATIONS, DE MALADIES AUTOIMMUNES ET DU DEVELOPPEMENT DE TUMEURS.
Publication
Application
Priority
- IL 10264692 A 19920726
- US 9307012 W 19930726
Abstract (en)
[origin: WO9402445A1] Non-peptidic Leu-Asp-Val (LDV) surrogates of formula (I), wherein X1 to X5 are the same or different C, N, O or S atoms, at least two of them being C, and the X1-X5 chain may be optionally substituted by radicals selected from halogen, hydrocarbyl, oxo, thioxo, amino and carboxyl, or the X1-X5 chain or part thereof may form part of a heterocyclic ring, and pharmaceutically acceptable salts thereof, inhibit cellular or molecular interactions which depend on recognition of the LDV sequence, and are useful for the treatment of inflammation and disorders involving interference with cell-matrix or cell-cell dependent immune processes, such as autoimmune diseases and allergy, and inhibition of tumour progression and metastasis.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 31/19 (2006.01); A61K 31/195 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07C 237/22 (2006.01); C07C 323/52 (2006.01); C07C 323/60 (2006.01); C07K 5/02 (2006.01); C07K 5/023 (2006.01); C07K 7/56 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07C 237/22 (2013.01); C07C 323/60 (2013.01); C07K 5/0202 (2013.01); C07K 7/56 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9402445A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9402445 A1 19940203; AU 4786093 A 19940214; CA 2140931 A1 19940127; EP 0652863 A1 19950517; IL 102646 A0 19930114; IL 102646 A 19960514; JP H07509469 A 19951019
DOCDB simple family (application)
US 9307012 W 19930726; AU 4786093 A 19930726; CA 2140931 A 19930726; EP 93918388 A 19930726; IL 10264692 A 19920726; JP 50474794 A 19930726