Global Patent Index - EP 0655888 A4

EP 0655888 A4 19970611 - PRODUCTION OF HUMAN HEMOGLOBIN IN TRANSGENIC PIGS.

Title (en)

PRODUCTION OF HUMAN HEMOGLOBIN IN TRANSGENIC PIGS.

Title (de)

HERSTELLUNG VON HUMANEN HÄMOGLOBIN IN TRANSGENEN SCHWEINEN.

Title (fr)

UTILISATION DE PORCS TRANSGENIQUES POUR LA PRODUCTION D'HEMOGLOBINE HUMAINE.

Publication

EP 0655888 A4 19970611 (EN)

Application

EP 93915317 A 19930611

Priority

  • US 9305629 W 19930611
  • US 89764892 A 19920612
  • US 98789092 A 19921208
  • US 3089793 A 19930315

Abstract (en)

[origin: WO9325071A1] The present invention relates to the use of transgenic pigs for the production of human hemoglobin in which, in certain embodiments, the pig beta globin promoter is used to facilitate the expression of human hemoglobin. The transgenic pigs of the invention may be used as an efficient and economical source of cell-free human hemoglobin that may be used for transfusions and other medical applications in humans.

IPC 1-7

A01K 67/00; A01K 67/027; C12N 15/90; C12P 21/06

IPC 8 full level

A01K 67/027 (2006.01); A61K 38/16 (2006.01); A61P 7/08 (2006.01); C07K 14/805 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A01K 67/0278 (2013.01); A61P 7/08 (2017.12); C07K 14/805 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/108 (2013.01); A01K 2267/01 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [Y] WO 8809179 A1 19881201 - SOMATOGENETICS INT [US], et al
  • [PX] WO 9222646 A1 19921223 - DNX CORP [US]
  • [XO] International symposium on the role of Biotechnologies in preventive oncology, San Remo, Italy, June 11-12 1992 & O'DONNELL, J.K. ET AL.: "Production of human hemoglobin in transgenic swine: an approach to a blood substitute", CANCER DETECTION AND PREVENTION, vol. 17, no. 2, 1993, pages 307 - 312, XP000606893
  • [X] BIEBER, F.A. & BRAUNITZER, G.: "Zur prä- und perinatalen Sauerstoffübertragung der Säuger : Die embryonalen Hämoglobinevom Hausschwein (Sus scrofa domestica)", HOPPE-SEYLER'S ZEITSCRIFT FÜR PHYSIOLOGISCHE CHEMIE, vol. 365, no. 3, March 1984 (1984-03-01), pages 321 - 334, XP000647018
  • [Y] HOFFMAN, S.J. ET AL.: "Expression of fully functional tetrameric human hemoglobin in Escherichia coli", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 87, no. 21, November 1990 (1990-11-01), WASHINGTON US, pages 8521 - 8525, XP002020074
  • [Y] LOOKER, D. ET AL.: "A human recombinant haemoglobin designed for use as a blood substitute", NATURE, vol. 356, no. 6366, 19 March 1992 (1992-03-19), LONDON GB, pages 258 - 260, XP002020075
  • See references of WO 9325071A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9325071 A1 19931223; AU 4534393 A 19940104; AU 687743 B2 19980305; CA 2137911 A1 19931223; EP 0655888 A1 19950607; EP 0655888 A4 19970611; FI 945829 A0 19941212; FI 945829 A 19950210; JP H07507921 A 19950907; NZ 253642 A 19961028

DOCDB simple family (application)

US 9305629 W 19930611; AU 4534393 A 19930611; CA 2137911 A 19930611; EP 93915317 A 19930611; FI 945829 A 19941212; JP 51277993 A 19930611; NZ 25364293 A 19930611