EP 0655924 A1 19950607 - A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING.
Title (en)
A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING.
Title (de)
EINE KOMBINATION VON MONOKLONALEN ANTIKÖRPERN GEGEN erbB-2 UND VERFAHREN ZUR IHRER NUTZUNG.
Title (fr)
COMBINAISON D'ANTICORPS MONOCLONAUX ANTI-erbB-2 ET PROCEDE POUR SON UTILISATION.
Publication
Application
Priority
- US 9208545 W 19921021
- US 90655592 A 19920630
Abstract (en)
[origin: WO9400136A1] The present invention relates to a combination of at least two monolconal antibodies which are capable of preventing and treating human malignancies wherein the malignant cells overexpress gp185erbB-2. The monoclonal antibodies of the combination recognize different epitopes of the gp185 expression product of erbB-2, therefore, the antibodies do not cross react with each other. Preferably, the combination decreases the expression product of the erbB-2 gene. In another embodiment, the combination does not essentially increase tyrosine phosphorylation of the gp185 expression product.
IPC 1-7
A61K 35/14; A61K 39/00; C12N 15/00; C07K 1/00; C07K 14/00; C07K 15/00; C07K 17/00
IPC 8 full level
C12N 15/02 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR)
A61K 39/00 (2013.01 - KR); A61P 35/00 (2017.12 - EP); C07K 16/22 (2013.01 - KR); C07K 16/32 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 2039/507 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9400136 A1 19940106; AU 3773393 A 19940124; AU 687346 B2 19980226; CA 2120745 A1 19940106; EP 0655924 A1 19950607; EP 0655924 A4 19960911; JP H08504172 A 19960507; KR 100269879 B1 20001016; KR 950700075 A 19950116
DOCDB simple family (application)
US 9208545 W 19921021; AU 3773393 A 19921021; CA 2120745 A 19921021; EP 93906955 A 19921021; JP 50230794 A 19921021; KR 19940701148 A 19940407