Global Patent Index - EP 0655924 A4

EP 0655924 A4 19960911 - A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING.

Title (en)

A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING.

Title (de)

EINE KOMBINATION VON MONOKLONALEN ANTIKÖRPERN GEGEN erbB-2 UND VERFAHREN ZUR IHRER NUTZUNG.

Title (fr)

COMBINAISON D'ANTICORPS MONOCLONAUX ANTI-erbB-2 ET PROCEDE POUR SON UTILISATION.

Publication

EP 0655924 A4 19960911 (EN)

Application

EP 93906955 A 19921021

Priority

  • US 9208545 W 19921021
  • US 90655592 A 19920630

Abstract (en)

[origin: WO9400136A1] The present invention relates to a combination of at least two monolconal antibodies which are capable of preventing and treating human malignancies wherein the malignant cells overexpress gp185erbB-2. The monoclonal antibodies of the combination recognize different epitopes of the gp185 expression product of erbB-2, therefore, the antibodies do not cross react with each other. Preferably, the combination decreases the expression product of the erbB-2 gene. In another embodiment, the combination does not essentially increase tyrosine phosphorylation of the gp185 expression product.

IPC 1-7

A61K 35/14; A61K 39/00; C12N 15/00; C07K 1/00; C07K 14/00; C07K 15/00; C07K 17/00

IPC 8 full level

C12N 15/02 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP KR)

A61K 39/00 (2013.01 - KR); A61P 35/00 (2017.12 - EP); C07K 16/22 (2013.01 - KR); C07K 16/32 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 2039/507 (2013.01 - EP)

Citation (search report)

  • [Y] EP 0331034 A2 19890906 - NEORX CORP [US]
  • [Y] WO 9105264 A1 19910418 - ONCOGENETICS PARTNERS [US]
  • [X] KASPRZYK ET AL: "THERAPY OF AN ANIMAL MODEL OF HUMAN GASTRIC CANCER USING A COMBINATION OF ANTI-ERBB-2 MONOCLONAL ANTIBODIES", CANCER RESEARCH, vol. 52, 15 May 1992 (1992-05-15), pages 2771 - 2776, XP002014292
  • See references of WO 9400136A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9400136 A1 19940106; AU 3773393 A 19940124; AU 687346 B2 19980226; CA 2120745 A1 19940106; EP 0655924 A1 19950607; EP 0655924 A4 19960911; JP H08504172 A 19960507; KR 100269879 B1 20001016; KR 950700075 A 19950116

DOCDB simple family (application)

US 9208545 W 19921021; AU 3773393 A 19921021; CA 2120745 A 19921021; EP 93906955 A 19921021; JP 50230794 A 19921021; KR 19940701148 A 19940407