EP 0661979 A1 19950712 - CROSS-LINKING OLIGONUCLEOTIDES FOR ENZYME-MEDIATED TRIPLE STRAND FORMATION.
Title (en)
CROSS-LINKING OLIGONUCLEOTIDES FOR ENZYME-MEDIATED TRIPLE STRAND FORMATION.
Title (de)
VERNETZEN VON OLIGONUKLEOTIDEN FÜR ENZYMVERMITTELTE DREIFACHSTRANGBILDUNG.
Title (fr)
OLIGONUCLEOTIDES A RETICULATION POUR LA FORMATION DE TRIPLE BRIN A MEDIATION ENZYMATIQUE.
Publication
Application
Priority
- US 9207101 W 19920819
- US 74813891 A 19910821
Abstract (en)
[origin: WO9303736A1] The invention disclosed is directed to cross-linking between specific sites on adjoining oligonucleotides or oligodeoxynucleotides wherein the nucleoside monomers used to effect the cross-linking are (alkylating substituent substituted) pyrazolol[3,4-d]pyrimidine ribosides or 2'-deoxyribosides. This cross-linking is assisted by the presence in mammalian host of a recombination enzyme such as RecA. The cross-linking of either double or triple stranded nucleic acids is expected to have utility in the inhibiting the expression of the targeted nucleic acids in vivo and as a diagnostic tool as well.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 48/00 (2006.01); C07D 487/04 (2006.01); C07H 19/04 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
C07H 19/04 (2013.01); C07H 21/00 (2013.01); C12Q 1/6839 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9303736 A1 19930304; EP 0661979 A1 19950712; EP 0661979 A4 19950913; JP H06509945 A 19941110
DOCDB simple family (application)
US 9207101 W 19920819; EP 92918930 A 19920819; JP 50462393 A 19920819