EP 0661982 A1 19950712 - METHOD FOR ANTAGONIZING INOSITOL 1,4,5-TRIPHOSPHATE.
Title (en)
METHOD FOR ANTAGONIZING INOSITOL 1,4,5-TRIPHOSPHATE.
Title (de)
ANTAGONISTEN DES INOSITOL-1,4,5-TRIPHOSPHAT.
Title (fr)
PROCEDE D'INHIBITION DE L'ACTIVITE DE L'INOSITOL 1,4,5-TRIPHOSPHATE.
Publication
Application
Priority
- US 9308168 W 19930830
- US 95239392 A 19920928
Abstract (en)
[origin: WO9407507A1] Oligomers of formula (I) have been demonstrated to be effective antagonists of inositol 1,4,5-triphosphate (IP3) by competitively vying with IP3 for binding sites. By competitively inhibiting the activity of IP3, the oligomers of this invention can modulate the release of intracellular calcium and elicit the resultant physiological effects.
IPC 1-7
IPC 8 full level
A61K 31/785 (2006.01); A61K 31/17 (2006.01); A61K 31/795 (2006.01); A61P 43/00 (2006.01); C07C 309/51 (2006.01); C08G 71/02 (2006.01)
CPC (source: EP KR)
A61K 31/795 (2013.01 - EP KR); A61P 43/00 (2017.12 - EP)
Citation (search report)
See references of WO 9407507A1
Citation (examination)
FEBS LETTERS, vol. 252, no. 1,2, 1989, pages 105-108; M.A. TONES ET AL.: 'THE EFFECT OF HEPARIN ON THE INOSITOL 1,4,5-TRISHOSPHATE RECEPTOR IN RAT LIVER NICROSOMES'
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9407507 A1 19940414; AU 4841793 A 19940426; AU 670962 B2 19960808; CA 2145681 A1 19940414; EP 0661982 A1 19950712; HU 9500891 D0 19950529; HU T70192 A 19950928; IL 107066 A0 19931228; IL 107066 A 19980104; JP H08502068 A 19960305; KR 950703347 A 19950920; MX 9305933 A 19940429; NO 951163 D0 19950327; NO 951163 L 19950327; NZ 256178 A 19970324; TW 260663 B 19951021; ZA 936978 B 19940418
DOCDB simple family (application)
US 9308168 W 19930830; AU 4841793 A 19930830; CA 2145681 A 19930830; EP 93921252 A 19930830; HU 9500891 A 19930830; IL 10706693 A 19930922; JP 50905494 A 19930830; KR 19950701166 A 19950327; MX 9305933 A 19930927; NO 951163 A 19950327; NZ 25617893 A 19930830; TW 82107787 A 19930922; ZA 936978 A 19930921