EP 0663838 A1 19950726 - STABLE, HIGHLY CONCENTRATED FORMULATIONS OF FLUORESCEIN DERIVATIVES.
Title (en)
STABLE, HIGHLY CONCENTRATED FORMULATIONS OF FLUORESCEIN DERIVATIVES.
Title (de)
STABILE HOCHKONZENTRIERTE FORMULIERUNGEN VON FLUORESCEINDERIVATEN.
Title (fr)
COMPOSITIONS STABLES HAUTEMENT CONCENTREES DE DERIVES DE LA FLUORESCEINE.
Publication
Application
Priority
- EP 93919243 A 19930902
- EP 9302367 W 19930902
- EP 92810695 A 19920910
Abstract (en)
[origin: WO9405331A1] The present invention relates to stable, highly concentrated formulations of certain fluorescein derivatives, the production of these formulations and their use, especially in the photodynamic therapy of secondary cataracts. The present invention primarily concerns an aqueous solution containing a fluorescein diester, especially a fluorescein di-low alkyl ester, particularly fluorescein diacetate, and a partially etherised (beta) cyclodextrin, wherein the ether substitutes are hydroxyethyl, hydroxypropyl or dihydroxypropyl groups, wherein part of the ether substitutes may be methyl or ethyl groups and the (beta) cyclodextrin ether has a solubility of over 1,8 g in 100 ml water, especially hydroxypropyl (beta) cyclodextrin.
IPC 1-7
IPC 8 full level
A61K 41/00 (2006.01); A61K 47/48 (2006.01)
CPC (source: EP KR US)
A61K 41/00 (2013.01 - KR); A61K 41/0057 (2013.01 - EP US); A61K 47/50 (2017.07 - KR); A61K 47/6951 (2017.07 - EP US); B82Y 5/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9405331A1
Citation (examination)
CHEMICAL ABSTRACTS, vol. 105, no. 19, 10. November 1986, Columbus, Ohio, US; abstract no. 164973g, & DISS. ABSTR. INT. B Bd. 64, Nr. 7 , 1986 Seite 2288 CHAU, SINH VAN 'DIABETIC CATARACT: PREVENTION BY PHOTOAFFINITY DRUG.' s
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9405331 A1 19940317; AU 4956193 A 19940329; CA 2143115 A1 19940317; EP 0663838 A1 19950726; FI 951092 A0 19950308; FI 951092 A 19950308; JP H08503928 A 19960430; KR 950703365 A 19950920; TW 251236 B 19950711; US 5573773 A 19961112
DOCDB simple family (application)
EP 9302367 W 19930902; AU 4956193 A 19930902; CA 2143115 A 19930902; EP 93919243 A 19930902; FI 951092 A 19950308; JP 50687494 A 19930902; KR 19950700947 A 19950310; TW 81107414 A 19920919; US 39299395 A 19950306